MRS in conjunction with C isotopic labeled substrates is the only noninvasive method of brain imaging for cell-specific energy and neurotransmitter metabolism. However the application of MRS by neuroscientists is hindered by a steep learning curve as well as technological barriers, which include the need for significant resource and expertise centralization. In the last cycle. Core 2 implemented and provided support for the use of a wide range of state-of-the-art MRS methods and combined studies of MRS with MRI (Core 1) and neurophysiological recordings (Core 3) in conjunction with project-specific data analysis (Core 4). Through new user recruitment as well as support and training. Core 2 now supports the work of 7 qualifying Pis funded by NINDS who along with 16 other NIH-funded Pis use multinuclear MRS to address fundamental questions in basic and clinical neuroscience. The impact of Core 2 is further shown by support of work in 26 NIH grants and 3 new research initiatives that led to ROI grants, training of 5 neuroscientists in the use of MRS methods, and contributing to 50 papers that led to 604 citations (for Core 2 alone this represents 50% of the total citations for 106 papers for al| Cores). For the next cycle, we will continue to implement, maintain, and support innovative multinuclear MRS methods for Core 2 users, support new research initiatives, train and provide mentorship for neuroscience Pis and their staff for Core 2 usage, integrate synergistic use of MR/neurophysiological measurements and project-specific data analysis, implement new Core 2 methods to support neuroscience Pis, and track Core 2 activities and disseminate/share resources to NIH community. The newly implemented applications will include a variety of multinuclear MRS methods for high-resolution metabolic imaging and RF induced heat deposition measurements. The overall goal of Core 2 is to enhance NINDS- and NIH-funded research.
Magnetic resonance spectroscopy (MRS) in conjunction with C isotopic labeled substrates is the only noninvasive method of brain imaging for cell-specific energy and neurotransmitter metabolism. The application of MRS by neuroscientists is obstructed by significant technological challenges requiring resource and expertise centralization. Core 2 will support and develop spectroscopic neurolmaging to advance NIH supported projects of direct relevance to public health, and consistent with the NINDS mission.
|Strohbehn, Garth; Coman, Daniel; Han, Liang et al. (2015) Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance. J Neurooncol 121:441-9|
|de Graaf, Robin A; De Feyter, Henk M; Rothman, Douglas L (2015) High-sensitivity, broadband-decoupled (13) C MR spectroscopy in humans at 7T using two-dimensional heteronuclear single-quantum coherence. Magn Reson Med 74:903-14|
|Huang, Yuegao; Coman, Daniel; Ali, Meser M et al. (2015) Lanthanide ion (III) complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate for dual biosensing of pH with chemical exchange saturation transfer (CEST) and biosensor imaging of redundant deviation in shifts (BIRDS). Contrast Media Mol Imaging 10:51-8|
|Maritim, Samuel; Huang, Yuegao; Coman, Daniel et al. (2014) Characterization of a lanthanide complex encapsulated with MRI contrast agents into liposomes for biosensor imaging of redundant deviation in shifts (BIRDS). J Biol Inorg Chem 19:1385-98|
|de Graaf, Robin A; Behar, Kevin L (2014) Detection of cerebral NAD(+) by in vivo (1)H NMR spectroscopy. NMR Biomed 27:802-9|
|Patel, Anant B; Lai, James C K; Chowdhury, Golam M I et al. (2014) Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle. Proc Natl Acad Sci U S A 111:5385-90|
|Shulman, Robert G; Hyder, Fahmeed; Rothman, Douglas L (2014) Insights from neuroenergetics into the interpretation of functional neuroimaging: an alternative empirical model for studying the brain's support of behavior. J Cereb Blood Flow Metab 34:1721-35|
|Juchem, Christoph; Herman, Peter; Sanganahalli, Basavaraju G et al. (2014) DYNAmic Multi-coIl TEchnique (DYNAMITE) shimming of the rat brain at 11.7?T. NMR Biomed 27:897-906|
|Lin, Ai-Ling; Coman, Daniel; Jiang, Lihong et al. (2014) Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity. J Cereb Blood Flow Metab 34:1440-3|
|Detyniecki, Kamil; Blumenfeld, Hal (2014) Consciousness of seizures and consciousness during seizures: are they related? Epilepsy Behav 30:6-9|
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