MRS in conjunction with C isotopic labeled substrates is the only noninvasive method of brain imaging for cell-specific energy and neurotransmitter metabolism. However the application of MRS by neuroscientists is hindered by a steep learning curve as well as technological barriers, which include the need for significant resource and expertise centralization. In the last cycle. Core 2 implemented and provided support for the use of a wide range of state-of-the-art MRS methods and combined studies of MRS with MRI (Core 1) and neurophysiological recordings (Core 3) in conjunction with project-specific data analysis (Core 4). Through new user recruitment as well as support and training. Core 2 now supports the work of 7 qualifying Pis funded by NINDS who along with 16 other NIH-funded Pis use multinuclear MRS to address fundamental questions in basic and clinical neuroscience. The impact of Core 2 is further shown by support of work in 26 NIH grants and 3 new research initiatives that led to ROI grants, training of 5 neuroscientists in the use of MRS methods, and contributing to 50 papers that led to 604 citations (for Core 2 alone this represents 50% of the total citations for 106 papers for al| Cores). For the next cycle, we will continue to implement, maintain, and support innovative multinuclear MRS methods for Core 2 users, support new research initiatives, train and provide mentorship for neuroscience Pis and their staff for Core 2 usage, integrate synergistic use of MR/neurophysiological measurements and project-specific data analysis, implement new Core 2 methods to support neuroscience Pis, and track Core 2 activities and disseminate/share resources to NIH community. The newly implemented applications will include a variety of multinuclear MRS methods for high-resolution metabolic imaging and RF induced heat deposition measurements. The overall goal of Core 2 is to enhance NINDS- and NIH-funded research.
Magnetic resonance spectroscopy (MRS) in conjunction with C isotopic labeled substrates is the only noninvasive method of brain imaging for cell-specific energy and neurotransmitter metabolism. The application of MRS by neuroscientists is obstructed by significant technological challenges requiring resource and expertise centralization. Core 2 will support and develop spectroscopic neurolmaging to advance NIH supported projects of direct relevance to public health, and consistent with the NINDS mission.
|Benveniste, Helene; Dienel, Gerald; Jacob, Zvi et al. (2018) Trajectories of Brain Lactate and Re-visited Oxygen-Glucose Index Calculations Do Not Support Elevated Non-oxidative Metabolism of Glucose Across Childhood. Front Neurosci 12:631|
|Thompson, Garth J; Sanganahalli, Basavaraju G; Baker, Keeley L et al. (2018) Spontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb. Neuroimage 172:586-596|
|Yu, Yuguo; Herman, Peter; Rothman, Douglas L et al. (2018) Evaluating the gray and white matter energy budgets of human brain function. J Cereb Blood Flow Metab 38:1339-1353|
|Johnson, Matthew B; Sun, Xingshen; Kodani, Andrew et al. (2018) Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size. Nature 556:370-375|
|Johnson, Frances K; Delpech, Jean-Christophe; Thompson, Garth J et al. (2018) Amygdala hyper-connectivity in a mouse model of unpredictable early life stress. Transl Psychiatry 8:49|
|Mortensen, Kristian N; Gjedde, Albert; Thompson, Garth J et al. (2018) Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain. Neural Plast 2018:6120925|
|Thompson, Garth J (2018) Neural and metabolic basis of dynamic resting state fMRI. Neuroimage 180:448-462|
|Juchem, Christoph; de Graaf, Robin A (2017) The public multi-coil information (PUMCIN) policy. Magn Reson Med 78:2042-2047|
|Hyder, Fahmeed; Rothman, Douglas L (2017) Advances in Imaging Brain Metabolism. Annu Rev Biomed Eng 19:485-515|
|Wang, Helen; Huang, Yuegao; Coman, Daniel et al. (2017) Network evolution in mesial temporal lobe epilepsy revealed by diffusion tensor imaging. Epilepsia 58:824-834|
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