MRS in conjunction with [13]C isotopic labeled substrates is the only noninvasive method of brain imaging for cell-specific energy and neurotransmitter metabolism. However the application of MRS by neuroscientists is hindered by a steep learning curve as well as technological barriers, which include the need for significant resource and expertise centralization. In the last cycle. Core 2 implemented and provided support for the use of a wide range of state-of-the-art MRS methods and combined studies of MRS with MRI (Core 1) and neurophysiological recordings (Core 3) in conjunction with project-specific data analysis (Core 4). Through new user recruitment as well as support and training. Core 2 now supports the work of 7 qualifying Pis funded by NINDS who along with 16 other NIH-funded Pis use multinuclear MRS to address fundamental questions in basic and clinical neuroscience. The impact of Core 2 is further shown by support of work in 26 NIH grants and 3 new research initiatives that led to ROI grants, training of 5 neuroscientists in the use of MRS methods, and contributing to 50 papers that led to 604 citations (for Core 2 alone this represents 50% of the total citations for 106 papers for al| Cores). For the next cycle, we will continue to implement, maintain, and support innovative multinuclear MRS methods for Core 2 users, support new research initiatives, train and provide mentorship for neuroscience Pis and their staff for Core 2 usage, integrate synergistic use of MR/neurophysiological measurements and project-specific data analysis, implement new Core 2 methods to support neuroscience Pis, and track Core 2 activities and disseminate/share resources to NIH community. The newly implemented applications will include a variety of multinuclear MRS methods for high-resolution metabolic imaging and RF induced heat deposition measurements. The overall goal of Core 2 is to enhance NINDS- and NIH-funded research.

Public Health Relevance

Magnetic resonance spectroscopy (MRS) in conjunction with [13]C isotopic labeled substrates is the only noninvasive method of brain imaging for cell-specific energy and neurotransmitter metabolism. The application of MRS by neuroscientists is obstructed by significant technological challenges requiring resource and expertise centralization. Core 2 will support and develop spectroscopic neurolmaging to advance NIH supported projects of direct relevance to public health, and consistent with the NINDS mission.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
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Special Emphasis Panel (ZNS1-SRB-B (38))
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Yale University
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Kaneko, Gen; Sanganahalli, Basavaraju G; Groman, Stephanie M et al. (2017) Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model. Biol Psychiatry 81:503-513
Chowdhury, Golam M I; Wang, Peili; Ciardi, Alisha et al. (2017) Impaired Glutamatergic Neurotransmission in the Ventromedial Hypothalamus May Contribute to Defective Counterregulation in Recurrently Hypoglycemic Rats. Diabetes 66:1979-1989
Wang, Helen; Huang, Yuegao; Coman, Daniel et al. (2017) Network evolution in mesial temporal lobe epilepsy revealed by diffusion tensor imaging. Epilepsia 58:824-834
Thompson, Garth J (2017) Neural and metabolic basis of dynamic resting state fMRI. Neuroimage :
Tricò, Domenico; Prinsen, Hetty; Giannini, Cosimo et al. (2017) Elevated ?-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents. J Clin Endocrinol Metab 102:2473-2481
Kundishora, Adam J; Gummadavelli, Abhijeet; Ma, Chanthia et al. (2017) Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation. Cereb Cortex 27:1964-1975
Chowdhury, G M I; Zhang, J; Thomas, M et al. (2017) Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects. Mol Psychiatry 22:120-126
Feng, Li; Motelow, Joshua E; Ma, Chanthia et al. (2017) Seizures and Sleep in the Thalamus: Focal Limbic Seizures Show Divergent Activity Patterns in Different Thalamic Nuclei. J Neurosci 37:11441-11454
Rao, Jyotsna U; Coman, Daniel; Walsh, John J et al. (2017) Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH. Sci Rep 7:7865
Prinsen, Hetty; de Graaf, Robin A; Mason, Graeme F et al. (2017) Reproducibility measurement of glutathione, GABA, and glutamate: Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7T. J Magn Reson Imaging 45:187-198

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