Management and analysis of the very large data sets with ultra-high information content acquired by the neurolmaging and neurophysiology Cores requires specialized expertise and resources. Core 4 implements and supports usage of state-of-the-art image processing and data analysis programs for neuroscientists using Cores 1, 2 and 3. While a large number of software analysis packages and methods have been developed for human MRI data, the packages available for animal MRI and MRS have been limited. To address these limitations Core 4 created a suite of tools optimized for processing of small animal MR data and integrated them with various commercial and in-house software, which together provides support for all software needs of QNMR Core Center scientists and collaborating Pis. Users rely on a server-based high-performance cluster that provides rapid data access, backup, and sharing. The qualifying user group of Core 4 consists of 11 Pis funded by NINDS who along with 17 other NIH-funded Pis use multi-modal MR/neurophysiology software tools to process data to answer fundamental questions in basic and clinical neuroscience. The impact of Core 4 of Yale's QNMR Core Center is evidenced by its support of 32 NIH grants and 9 new research initiatives that led to papers and grants, the training of 5 neuroscientists (3 in NINDS PI laboratories) in advanced MRI/MRS data analysis and processing, and the use of Core 4 developed software in 51 papers that led to 388 citations (for Core 4 alone this represents 32% of the total citations for 106 papers for all Cores). For the next cycle, we will continue to implement, maintain, arid support innovative advanced and user-specific data analysis tools for Core 4 users, support new research initiatives, train and provide mentorship for neuroscience Pis and their personnel for Core 4 usage, facilitate synergistic use of MR/neurophysiological measurements and project specific data analysis, implement new image processing and data analysis methods to support neuroscience Pis, and track Core 4 activities and disseminate/share resources to NIH community. The implemented methods include user-specific tools needed to efficiently analyze cross-modal data to enhance NINDS- and NIH-funded research.

Public Health Relevance

Management and analysis of very large data sets with ultra-high information content acquired by the neurolmaging and neurophysiology cores requires specialized expertise and resources. Core 4 will support the development and integration of data manipulation and analysis tools by neuroscientists using all other Cores. The goals of this Core will advance NIH-supported projects of direct relevance to public health, and is consistent with the NINDS mission to promote treatment of neurological disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
2P30NS052519-06A1
Application #
8732259
Study Section
Special Emphasis Panel (ZNS1-SRB-B (38))
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
6
Fiscal Year
2014
Total Cost
$118,781
Indirect Cost
$47,441
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Strohbehn, Garth; Coman, Daniel; Han, Liang et al. (2015) Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance. J Neurooncol 121:441-9
de Graaf, Robin A; De Feyter, Henk M; Rothman, Douglas L (2015) High-sensitivity, broadband-decoupled (13) C MR spectroscopy in humans at 7T using two-dimensional heteronuclear single-quantum coherence. Magn Reson Med 74:903-14
Huang, Yuegao; Coman, Daniel; Ali, Meser M et al. (2015) Lanthanide ion (III) complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate for dual biosensing of pH with chemical exchange saturation transfer (CEST) and biosensor imaging of redundant deviation in shifts (BIRDS). Contrast Media Mol Imaging 10:51-8
Maritim, Samuel; Huang, Yuegao; Coman, Daniel et al. (2014) Characterization of a lanthanide complex encapsulated with MRI contrast agents into liposomes for biosensor imaging of redundant deviation in shifts (BIRDS). J Biol Inorg Chem 19:1385-98
de Graaf, Robin A; Behar, Kevin L (2014) Detection of cerebral NAD(+) by in vivo (1)H NMR spectroscopy. NMR Biomed 27:802-9
Patel, Anant B; Lai, James C K; Chowdhury, Golam M I et al. (2014) Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle. Proc Natl Acad Sci U S A 111:5385-90
Shulman, Robert G; Hyder, Fahmeed; Rothman, Douglas L (2014) Insights from neuroenergetics into the interpretation of functional neuroimaging: an alternative empirical model for studying the brain's support of behavior. J Cereb Blood Flow Metab 34:1721-35
Juchem, Christoph; Herman, Peter; Sanganahalli, Basavaraju G et al. (2014) DYNAmic Multi-coIl TEchnique (DYNAMITE) shimming of the rat brain at 11.7?T. NMR Biomed 27:897-906
Lin, Ai-Ling; Coman, Daniel; Jiang, Lihong et al. (2014) Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity. J Cereb Blood Flow Metab 34:1440-3
Detyniecki, Kamil; Blumenfeld, Hal (2014) Consciousness of seizures and consciousness during seizures: are they related? Epilepsy Behav 30:6-9

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