This is a proposal for an NINDS Institutional Center Core, the Informatics Center for Neurogenetics and Neurogenomics (ICNN) at UCLA. As with other areas of biomedical science, the post-genome era raises the prospect of transformational advances in neuroscience research. Neuroscience faces special challenges, however, in analysis, interpretation, and management of the vast quantities of information generated by genetic and genomic technologies. The phenotypic and organizational complexity of the nervous system calls for distinct analytical and informatics strategies and expertise. The ICNN will provide advanced analysis and informatics support to a highly interactive user group consisting of neuroscientists at UCLA, who are conducting basic, clinical, and translational research. These investigators have access to excellent facilities for genetics and genomics experimentation;the lack of corresponding resources in analysis and informatics constitutes a bottleneck in their research. ICNN faculty experts in statistical genetics, gene expression analysis, and bioinformatics will oversee the activities of highly-trained staff members who will accomplish three goals: 1) Providing expert consultation and analyses for neurogenetics and neurogenomics projects;2) Developing and maintaining a shared computing resource that will include a computational cluster for computation-intensive analyses, web-servers and state of the art software tools for a wide range of applications (including user-friendly versions of public databases, as well as workstations on which ICNN users will be trained to employ these tools;3) Providing hands-on training in analysis and informatics to the users.

Public Health Relevance

Scientists are increasingly focusing their efforts to understand and devise better treatments for brain diseases on investigations of the whole genomes of humans and other mammals. The vast amounts of data generated through these studies are overwhelming the capacity of individual laboratories to conduct optimal analyses and adequately manage information. The Informatics Center for Neurogenetics and Neurogenomics at UCLA will provide a shared resource for sophisticated data analyses and computing facilities for a group of investigators who are using genetics and genome science in studies of a wide range of devastating brain diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS062691-05
Application #
8593318
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Program Officer
Talley, Edmund M
Project Start
2009-08-01
Project End
2014-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
5
Fiscal Year
2014
Total Cost
$692,583
Indirect Cost
$242,854
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Lui, Hansen; Zhang, Jiasheng; Makinson, Stefanie R et al. (2016) Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell 165:921-35
Sirkis, Daniel W; Bonham, Luke W; Aparicio, Renan E et al. (2016) Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression. Acta Neuropathol Commun 4:98
Watson, Annie; Pribadi, Mochtar; Chowdari, Kodavali et al. (2016) C9orf72 repeat expansions that cause frontotemporal dementia are detectable among patients with psychosis. Psychiatry Res 235:200-2
Paul, Sharan; Pflieger, Lance; Dansithong, Warunee et al. (2016) Co-expression networks in generation of induced pluripotent stem cells. Biol Open 5:300-10
Ahuja, Umesh; Shokeen, Bhumika; Cheng, Ning et al. (2016) Differential regulation of type III secretion and virulence genes in Bordetella pertussis and Bordetella bronchiseptica by a secreted anti-σ factor. Proc Natl Acad Sci U S A 113:2341-8
Duong, Dat; Zou, Jennifer; Hormozdiari, Farhad et al. (2016) Using genomic annotations increases statistical power to detect eGenes. Bioinformatics 32:i156-i163
Kuokkanen, Satu; Polotsky, Alex J; Chosich, Justin et al. (2016) Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function. Syst Biol Reprod Med 62:227-42
Laks, Dan R; Ta, Lisa; Crisman, Thomas J et al. (2016) Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma. Mol Cancer Ther 15:1271-8
Langfelder, Peter; Cantle, Jeffrey P; Chatzopoulou, Doxa et al. (2016) Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. Nat Neurosci 19:623-33
Schroeder, Analyne M; Wang, Huei Bin; Park, Saemi et al. (2016) Cardiac Dysfunction in the BACHD Mouse Model of Huntington's Disease. PLoS One 11:e0147269

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