In this Institutional Center Core Grant to Support Neuroscience Research, we propose to establish an innovative Neural Imaging Center composed of four Core facilities that will serve NINDS-funded Harvard Medical School (HMS) and Children's Hospital Boston (CHB) investigators. These state-of-the-art facilities will provide important new resources to the HMS and CHB neuroscience community, and will perform essential services that are difficult and impractical for individual laboratories to provide on ther own. The Imaging Center will be composed of an Administrative Core, a High-Content Cellular Imaging Core, an immunohistochemistry-based Array Tomography Core, and a Super-resolution Imaging Core. The experimental opportunities and innovative services provided by the Imaging Center will give area neuroscientists access to unique equipment and training in several new cutting-edge methodologies, greatly benefiting the research programs of NINDS-funded investigators at these institutions. Moreover, the Center will function as the centerpiece of a concerted effort to strengthen ties between the neuroscience communities at HMS and CHB. Thus, a major focus of this Center will be to serve as a nexus for collaborative interactions. To this end, we propose not only to establish a set of core facilities, but also to adopt several strategies that reduce the barriers to their widespread utilization, including provisions for informal education regarding core methodologies and significant technical support. Through the development of this Center, we hope to shift from a complete reliance on individual laboratory-centered research to a more cost-effective and productive use of extraordinary cores while further deepening existing ties between these two vibrant neuroscience communities.

Public Health Relevance

We propose to establish a Neural Imaging Center to serve NINDS-funded Harvard Medical School and Children's Hospital Boston investigators. These facilities will provide important new resources and perform essential services that are difficult and impractical for individual laboratories to perform on their own, thereby accelerating the pace of neuroscience research at these institutions.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
Project #
Application #
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Program Officer
Talley, Edmund M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Harvard Medical School
Schools of Medicine
United States
Zip Code
Chow, Brian Wai; Gu, Chenghua (2017) Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation. Neuron 93:1325-1333.e3
Chen, Yao; Granger, Adam J; Tran, Trinh et al. (2017) Endogenous G?q-Coupled Neuromodulator Receptors Activate Protein Kinase A. Neuron 96:1070-1083.e5
Abraira, Victoria E; Kuehn, Emily D; Chirila, Anda M et al. (2017) The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell 168:295-310.e19
Cho, Jin-Hyung; Rendall, Sam D; Gray, Jesse M (2017) Brain-wide maps of Fos expression during fear learning and recall. Learn Mem 24:169-181
Zoeller, Jason J; Bronson, Roderick T; Selfors, Laura M et al. (2017) Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo. NPJ Breast Cancer 3:18
Lutas, Andrew; Lahmann, Carolina; Soumillon, Magali et al. (2016) The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons. Elife 5:
Straub, Christoph; Saulnier, Jessica Lizette; B├Ęgue, Aurelien et al. (2016) Principles of Synaptic Organization of GABAergic Interneurons in the Striatum. Neuron 92:84-92
Jackman, Skyler L; Turecek, Josef; Belinsky, Justine E et al. (2016) The calcium sensor synaptotagmin 7 is required for synaptic facilitation. Nature 529:88-91
Dauth, Stephanie; Grevesse, Thomas; Pantazopoulos, Harry et al. (2016) Extracellular matrix protein expression is brain region dependent. J Comp Neurol 524:1309-36
Park, Sung-Jin; Gazzola, Mattia; Park, Kyung Soo et al. (2016) Phototactic guidance of a tissue-engineered soft-robotic ray. Science 353:158-62

Showing the most recent 10 out of 44 publications