The Neuroscience Center Behavior Core will establish a centralized resource for the analysis of animal behavior. The objectives of this core resource will be to provide uniform behavioral analysis of rodents employing a variety of behavioral platforms appropriate for the research needs of Salk Institute Neuroscience Center faculty and to provide expertise for the interpretation of results. Behavioral studies are an important component of modern neuroscience research. For example, careful analysis of changes in rat behavior in the radial water maze showed that the ability to learn new tasks decreases with age. These changes were eventually found to be reflected at the cellular level, in particular, in the dentate gyrus of the hippocampus where aging is associated with a reduction in the number of axons in the medial perforant path, as well as the density of synaptic contacts impinging on granule cells. Subsequently this reduction in the input to the hippocampus was found accompanied by a decrease in synaptic plasticity, longterm potentiation has a higher threshold and lasts for a shorter time in aged animals, and there is an agedependent decrease in NMDA receptor-mediated responses - all discoveries stemming from the initial analysis of animal behavior.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS072031-03
Application #
8517841
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
3
Fiscal Year
2013
Total Cost
$258,261
Indirect Cost
$122,771
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
078731668
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Hilde, Kathryn L; Levine, Ariel J; Hinckley, Christopher A et al. (2016) Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position. Neuron 91:763-76
Kawaguchi, Daichi; Sahara, Setsuko; Zembrzycki, Andreas et al. (2016) Generation and analysis of an improved Foxg1-IRES-Cre driver mouse line. Dev Biol 412:139-47
Xu, Jiqing; de Winter, Fred; Farrokhi, Catherine et al. (2016) Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model. Sci Rep 6:31692
Kador, Karl E; Grogan, Shawn P; Dorthé, Erik W et al. (2016) Control of Retinal Ganglion Cell Positioning and Neurite Growth: Combining 3D Printing with Radial Electrospun Scaffolds. Tissue Eng Part A 22:286-94
Sekiguchi, Kohei J; Shekhtmeyster, Pavel; Merten, Katharina et al. (2016) Imaging large-scale cellular activity in spinal cord of freely behaving mice. Nat Commun 7:11450
Perez-Garcia, Carlos G; O'Leary, Dennis D M (2016) Formation of the Cortical Subventricular Zone Requires MDGA1-Mediated Aggregation of Basal Progenitors. Cell Rep 14:560-71
Kerman, Bilal E; Kim, Hyung Joon; Padmanabhan, Krishnan et al. (2015) In vitro myelin formation using embryonic stem cells. Development 142:2213-25
Taylor-Weiner, Hermes; Ravi, Neeraja; Engler, Adam J (2015) Traction forces mediated by integrin signaling are necessary for definitive endoderm specification. J Cell Sci 128:1961-8
Wassenaar, Jean W; Boss, Gerry R; Christman, Karen L (2015) Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions. Biomaterials 64:108-14
Adams, Michael W; Loftus, Andrew F; Dunn, Sarah E et al. (2015) Light Sheet Fluorescence Microscopy (LSFM). Curr Protoc Cytom 71:12.37.1-15

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