The Salk Institute for Biological Studies requests support for a new Ceriter Core Grant for Neuroscience Research. Since the founding ofthe Institute in the 1960s, neuroscience has grown to be the major research emphasis of Salk faculty. Over half of the faculty, heading.32 Institute laboratories, are currently engaged primarily in neuroscience research. The major research interests ofthe faculty are grouped into several broad programmatic areas: Clinical and Translational Neuroscience, Molecular and Cellular Neuroscience, Neural Development, and Systems Neuroscience. Seventeen research projects, supporting twelve faculty as principal investigators, are currently funded by NINDS. These awards include nine independent R01/R37 research projects, an active RC2 (Grand Opportunities) award, a K99, and a POI program project. Nine Salk investigators are either current or past Jacob Javits awardees.
The specific aim of this Center Core Grant application is to provide support for key resources that are needed for current and future NINDS-funded research projects. Three new core resources are proposed: 1) a Genome Manipulation Core, providing services to produce gene-targeted ES cell lines for in vivo and in vitro models for functional analysis of genes and neurologic disease, 2) an Imaging Core, focusing on dedicated support for TEM ultrastructural imaging and fostering integrated structural analysis across multiple advanced imaging platforms, and 3) a Behavior Core, providing both dedicated expertise in small animal behavioral analysis and consistency across different testing modalities. The management of these cores will focus first on providing support for the eight Salk Institute investigators with current NINDS-funded R01/R37 research programs. Any excess core capacity will be made available to other investigators at The Salk Institute who have research projects that are consistent with the mission of NINDS. This infrastructure program will provide core services that will facilitate application of continually evolving advanced technologies to the NINDS-funded research projects at the Salk Institute, and leverage existing funding as a resource multiplier to better advance these projects in addressing important problems relevant to the NINDS mission.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS072031-03
Application #
8517842
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
3
Fiscal Year
2013
Total Cost
$224,323
Indirect Cost
$97,501
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
078731668
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Hilde, Kathryn L; Levine, Ariel J; Hinckley, Christopher A et al. (2016) Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position. Neuron 91:763-76
Kawaguchi, Daichi; Sahara, Setsuko; Zembrzycki, Andreas et al. (2016) Generation and analysis of an improved Foxg1-IRES-Cre driver mouse line. Dev Biol 412:139-47
Xu, Jiqing; de Winter, Fred; Farrokhi, Catherine et al. (2016) Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model. Sci Rep 6:31692
Kador, Karl E; Grogan, Shawn P; Dorthé, Erik W et al. (2016) Control of Retinal Ganglion Cell Positioning and Neurite Growth: Combining 3D Printing with Radial Electrospun Scaffolds. Tissue Eng Part A 22:286-94
Sekiguchi, Kohei J; Shekhtmeyster, Pavel; Merten, Katharina et al. (2016) Imaging large-scale cellular activity in spinal cord of freely behaving mice. Nat Commun 7:11450
Perez-Garcia, Carlos G; O'Leary, Dennis D M (2016) Formation of the Cortical Subventricular Zone Requires MDGA1-Mediated Aggregation of Basal Progenitors. Cell Rep 14:560-71
Kerman, Bilal E; Kim, Hyung Joon; Padmanabhan, Krishnan et al. (2015) In vitro myelin formation using embryonic stem cells. Development 142:2213-25
Taylor-Weiner, Hermes; Ravi, Neeraja; Engler, Adam J (2015) Traction forces mediated by integrin signaling are necessary for definitive endoderm specification. J Cell Sci 128:1961-8
Wassenaar, Jean W; Boss, Gerry R; Christman, Karen L (2015) Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions. Biomaterials 64:108-14
Adams, Michael W; Loftus, Andrew F; Dunn, Sarah E et al. (2015) Light Sheet Fluorescence Microscopy (LSFM). Curr Protoc Cytom 71:12.37.1-15

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