The Salk Institute for Biological Studies requests support for a new Ceriter Core Grant for Neuroscience Research. Since the founding ofthe Institute in the 1960s, neuroscience has grown to be the major research emphasis of Salk faculty. Over half of the faculty, heading.32 Institute laboratories, are currently engaged primarily in neuroscience research. The major research interests ofthe faculty are grouped into several broad programmatic areas: Clinical and Translational Neuroscience, Molecular and Cellular Neuroscience, Neural Development, and Systems Neuroscience. Seventeen research projects, supporting twelve faculty as principal investigators, are currently funded by NINDS. These awards include nine independent R01/R37 research projects, an active RC2 (Grand Opportunities) award, a K99, and a POI program project. Nine Salk investigators are either current or past Jacob Javits awardees.
The specific aim of this Center Core Grant application is to provide support for key resources that are needed for current and future NINDS-funded research projects. Three new core resources are proposed: 1) a Genome Manipulation Core, providing services to produce gene-targeted ES cell lines for in vivo and in vitro models for functional analysis of genes and neurologic disease, 2) an Imaging Core, focusing on dedicated support for TEM ultrastructural imaging and fostering integrated structural analysis across multiple advanced imaging platforms, and 3) a Behavior Core, providing both dedicated expertise in small animal behavioral analysis and consistency across different testing modalities. The management of these cores will focus first on providing support for the eight Salk Institute investigators with current NINDS-funded R01/R37 research programs. Any excess core capacity will be made available to other investigators at The Salk Institute who have research projects that are consistent with the mission of NINDS. This infrastructure program will provide core services that will facilitate application of continually evolving advanced technologies to the NINDS-funded research projects at the Salk Institute, and leverage existing funding as a resource multiplier to better advance these projects in addressing important problems relevant to the NINDS mission.
|Wen, Jessica H; Vincent, Ludovic G; Fuhrmann, Alexander et al. (2014) Interplay of matrix stiffness and protein tethering in stem cell differentiation. Nat Mater 13:979-87|
|Firth, Amy L; Dargitz, Carl T; Qualls, Susan J et al. (2014) Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. Proc Natl Acad Sci U S A 111:E1723-30|
|Vilar, Marçal; Sung, Tsung-Chang; Chen, Zhijiang et al. (2014) Heterodimerization of p45-p75 modulates p75 signaling: structural basis and mechanism of action. PLoS Biol 12:e1001918|
|Seidel, Shannon; Bruce, James; Leblanc, Mathias et al. (2013) ZASC1 knockout mice exhibit an early bone marrow-specific defect in murine leukemia virus replication. Virol J 10:130|
|Chien, Yuan-Hung; Werner, Michael E; Stubbs, Jennifer et al. (2013) Bbof1 is required to maintain cilia orientation. Development 140:3468-77|
|Sung, Tsung-Chang; Chen, Zhijiang; Thuret, Sandrine et al. (2013) P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. PLoS One 8:e69286|