The Salk Institute for Biological Studies requests support for a new Ceriter Core Grant for Neuroscience Research. Since the founding ofthe Institute in the 1960s, neuroscience has grown to be the major research emphasis of Salk faculty. Over half of the faculty, heading.32 Institute laboratories, are currently engaged primarily in neuroscience research. The major research interests ofthe faculty are grouped into several broad programmatic areas: Clinical and Translational Neuroscience, Molecular and Cellular Neuroscience, Neural Development, and Systems Neuroscience. Seventeen research projects, supporting twelve faculty as principal investigators, are currently funded by NINDS. These awards include nine independent R01/R37 research projects, an active RC2 (Grand Opportunities) award, a K99, and a POI program project. Nine Salk investigators are either current or past Jacob Javits awardees.
The specific aim of this Center Core Grant application is to provide support for key resources that are needed for current and future NINDS-funded research projects. Three new core resources are proposed: 1) a Genome Manipulation Core, providing services to produce gene-targeted ES cell lines for in vivo and in vitro models for functional analysis of genes and neurologic disease, 2) an Imaging Core, focusing on dedicated support for TEM ultrastructural imaging and fostering integrated structural analysis across multiple advanced imaging platforms, and 3) a Behavior Core, providing both dedicated expertise in small animal behavioral analysis and consistency across different testing modalities. The management of these cores will focus first on providing support for the eight Salk Institute investigators with current NINDS-funded R01/R37 research programs. Any excess core capacity will be made available to other investigators at The Salk Institute who have research projects that are consistent with the mission of NINDS. This infrastructure program will provide core services that will facilitate application of continually evolving advanced technologies to the NINDS-funded research projects at the Salk Institute, and leverage existing funding as a resource multiplier to better advance these projects in addressing important problems relevant to the NINDS mission.

Public Health Relevance

Neurological diseases have significant impact on public health, and The Salk Institute for Biological Studies is a unique research environment supporting high impact research in the neurosciences. An NINDS Center Core Grant will allow the Institute to expand support for neuroscience research through creating several new centralized research services.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Salk Institute for Biological Studies
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Daugherty, Daniel; Goldberg, Joshua; Fischer, Wolfgang et al. (2017) A novel Alzheimer's disease drug candidate targeting inflammation and fatty acid metabolism. Alzheimers Res Ther 9:50
Howard, Christopher D; Li, Hao; Geddes, Claire E et al. (2017) Dynamic Nigrostriatal Dopamine Biases Action Selection. Neuron 93:1436-1450.e8
Tufail, Yusuf; Cook, Daniela; Fourgeaud, Lawrence et al. (2017) Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. Neuron 93:574-586.e8
Cheng, Longzhen; Duan, Bo; Huang, Tianwen et al. (2017) Identification of spinal circuits involved in touch-evoked dynamic mechanical pain. Nat Neurosci 20:804-814
Curchoe, Carol Lynn; Manor, Uri (2017) Actin Cytoskeleton-Mediated Constriction of Membrane Organelles via Endoplasmic Reticulum Scaffolding. ACS Biomater Sci Eng 3:2727-2732
Chen, Zhijiang; Donnelly, Christopher R; Dominguez, Bertha et al. (2017) p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. Cell Rep 21:707-720
Sonntag, Tim; Vaughan, Joan M; Montminy, Marc (2017) 14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs). FEBS J :
Farhy-Tselnicker, Isabella; van Casteren, Adriana C M; Lee, Aletheia et al. (2017) Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation. Neuron 96:428-445.e13
Hirai, Maretoshi; Arita, Yoh; McGlade, C Jane et al. (2017) Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest 127:569-582
Chu, Qian; Rathore, Annie; Diedrich, Jolene K et al. (2017) Identification of Microprotein-Protein Interactions via APEX Tagging. Biochemistry 56:3299-3306

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