The goal of this application is to establish a "Center for Neuroscience Research in Non-Human Primates" (CNRN) at the University of Pittsburgh. Each of the Center's six Cores - (1) Veterinary Services;(2) Surgery;(3) Histology;(4) Imaging;(5) Bioengineering, Computing, and Electronics;and (6) Administration - is designed to meet the specialized needs for neuroscience-related research in awake, behaving non-human primates (NHPs). The CNRN has 3 main goals: (1) To support the neuroscience research of current major users of non-human primates;(2) To make resources available to Early Stage Investigators who are setting up labs to work with NHPs;and (3) To enable investigators who work with other model systems to perform "proof of principle" studies in NHPs. The Center's resources will be available not only to investigators at the University of Pittsburgh, but also to those at our sister institution, Carnegie Mellon University. The CNRN does not overlap or duplicate other facilities within the University. Indeed, certain types of research will only be possible because of the existence of the Center. The Center has 9 "NINDS-qualifying" research projects directed by 6 separate Principal Investigators. Overall, the Center will serve the needs of faculty in multiple Basic Science (4) and Clinical Departments (11), including 17 heavy users, 6 Early Stage Investigators, and 11 investigators who have expressed an interest in testing their ideas in a NHP model. In summary, the CNRN will be a critical resource for at least 28 scientists with 50 grants (30 of which are NINDS grants) at 2 major institutions, the University of Pittsburgh and Carnegie Mellon University. The Center will serve multiple Centers of Excellence at the University of Pittsburgh including those focused on topics of primary interest to the mission of NINDS, such as Parkinson's and Huntington's Diseases, traumatic brain and spinal cord injury, stroke and the normal and abnormal control of movement.
The Center for Neuroscience Research in Non-Human Primates is designed to support research projects for which non-human primates are the most appropriate model system. The Center will be a resource for investigators seeking to understand normal brain function and to develop treatments for neurological disorders including neurodegenerative diseases, traumatic brain and spinal cord injury, and stroke.
|Jin, Tao; Mehrens, Hunter; Wang, Ping et al. (2016) Glucose metabolism-weighted imaging with chemical exchange-sensitive MRI of 2-deoxyglucose (2DG) in brain: Sensitivity and biological sources. Neuroimage 143:82-90|
|Schwartz, Andrew B (2016) Movement: How the Brain Communicates with the World. Cell 164:1122-35|
|Ohbayashi, Machiko; Picard, Nathalie; Strick, Peter L (2016) Inactivation of the Dorsal Premotor Area Disrupts Internally Generated, But Not Visually Guided, Sequential Movements. J Neurosci 36:1971-6|
|Dum, Richard P; Levinthal, David J; Strick, Peter L (2016) Motor, cognitive, and affective areas of the cerebral cortex influence the adrenal medulla. Proc Natl Acad Sci U S A 113:9922-7|
|Degenhart, Alan D; Eles, James; Dum, Richard et al. (2016) Histological evaluation of a chronically-implanted electrocorticographic electrode grid in a non-human primate. J Neural Eng 13:046019|
|Shakkottai, Vikram G; Batla, Amit; Bhatia, Kailash et al. (2016) Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia. Cerebellum :|
|Golub, Matthew D; Chase, Steven M; Batista, Aaron P et al. (2016) Brain-computer interfaces for dissecting cognitive processes underlying sensorimotor control. Curr Opin Neurobiol 37:53-8|
|Pasquereau, Benjamin; DeLong, Mahlon R; Turner, Robert S (2016) Primary motor cortex of the parkinsonian monkey: altered encoding of active movement. Brain 139:127-43|
|Zimnik, Andrew J; Nora, Gerald J; Desmurget, Michel et al. (2015) Movement-related discharge in the macaque globus pallidus during high-frequency stimulation of the subthalamic nucleus. J Neurosci 35:3978-89|
|Kozai, Takashi D Y; Catt, Kasey; Li, Xia et al. (2015) Mechanical failure modes of chronically implanted planar silicon-based neural probes for laminar recording. Biomaterials 37:25-39|
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