1. HIGH AND ULTRAHIGH FIELD IMAGE ACQUISITION AND ENGINEERING PI: Pierre-Francois van de Moortlele, PhD Core Aims The long-term goal of this core is to provide the means to enhance, broaden and accelerate a large array of ambitious neuroscience research projects that are increasingly utilizing high (3 and 4T) and ultrahigh (7T and above) field MR Imaging instruments and novel image acquisition and reconstruction techniques to investigate brain structure and function. Multiple studies have now amply demonstrated that MRI at higher magnetic fields can provide significant advantages in signal-to-noise ratio (SNR), spatial resolution, anatomical delineation, and anatomical and functional contrast. When combined with the appropriate imaging methods, these gains can be transformative in basic and translational neuroscience projects. However, access to such advanced capabilities by neuroscience researchers is virtually impossible outside the context of a collaborative and multidisciplinary relationship, especially (but not only) when instrumentation at the cutting-edge of the field, such as those operating at high (HF) and ultrahigh fields (UHF), and advanced, asof- yet commercially unavailable imaging methods are employed.
The aim of this core is to provide the necessary support and infrastructure that will allow a large community of NINDS funded investigators to utilize advanced imaging methodologies and instrumentation in CMRR where there exists a large parallel effort (funded by other sources) on instrumentation and methodology development.
|Hakkarainen, Hanne; Sierra, Alejandra; Mangia, Silvia et al. (2016) MRI relaxation in the presence of fictitious fields correlates with myelin content in normal rat brain. Magn Reson Med 75:161-8|
|McKay, Jessica; TkÃ¡Ä, Ivan (2016) Quantitative in vivo neurochemical profiling in humans: where are we now? Int J Epidemiol 45:1339-1350|
|Lu, Ming; Zhu, Xiao-Hong; Chen, Wei (2016) In vivo (31) P MRS assessment of intracellular NAD metabolites and NAD(+) /NADH redox state in human brain at 4 T. NMR Biomed 29:1010-7|
|Schallmo, Michael-Paul; Grant, Andrea N; Burton, Philip C et al. (2016) The effects of orientation and attention during surround suppression of small image features: A 7 Tesla fMRI study. J Vis 16:19|
|Kennedy, James T; Collins, Paul F; Luciana, Monica (2016) Higher Adolescent Body Mass Index Is Associated with Lower Regional Gray and White Matter Volumes and Lower Levels of Positive Emotionality. Front Neurosci 10:413|
|Pardon, Marie-Christine; Yanez Lopez, Maria; Yuchun, Ding et al. (2016) Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models. Sci Rep 6:19880|
|Lou, Song; Lepak, Victoria C; Eberly, Lynn E et al. (2016) Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress. Hum Mol Genet 25:2813-2826|
|Bernstein, Gail A; Mueller, Bryon A; Schreiner, Melinda Westlund et al. (2016) Abnormal striatal resting-state functional connectivity in adolescents with obsessive-compulsive disorder. Psychiatry Res 247:49-56|
|Qiu, Cheng; Burton, Philip C; Kersten, Daniel et al. (2016) Responses in early visual areas to contour integration are context dependent. J Vis 16:19|
|Farooq, Hamza; Xu, Junqian; Nam, Jung Who et al. (2016) Microstructure Imaging of Crossing (MIX) White Matter Fibers from diffusion MRI. Sci Rep 6:38927|
Showing the most recent 10 out of 123 publications