Abstract

2. MOLECULAR IMAGING CORE PI: Michael Garwood, PhD;co-PI: Jerry Froelich MD;Co-I Gulin Oz CORE AIM Magnetic resonance spectroscopy (MRS) and positron emission tomography (PET) are two major modalities of molecular imaging, which allow direct assessment of metabolite and tracer concentrations in brain in vivo. They are critically important in studies of neurochemistry, brain function and perfusion, and can provide surrogate markers to detect brain diseases, to monitor disease progression, and to evaluate the effectiveness of novel therapies. With MRS, the richness of the biochemical information and the accuracy of metabolite quantification are strongly linked to spectral quality. In this regard, the ultrahigh field MRI/MRS systems in the CMRR, particulariy the new 16.4 T rodent capable system, the 9.4 T animal system with [13]C DNP hyperpolarizer, the 7T human systems, and the future 10.5 T human system, offer major advantages. In particular, they provide superior signal-to-noise ratio (SNR) and spectral resolution, for improved reproducibility in the detection and quantification of brain metabolites. In addition, brain scans with human PET/CT, microPET/CT, and Neuro SPECT are now available in the recently expanded CMRR.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
1P30NS076408-01A1
Application #
8538134
Study Section
Special Emphasis Panel (ZNS1-SRB-R (59))
Project Start
Project End
Budget Start
2012-09-30
Budget End
2013-06-30
Support Year
1
Fiscal Year
2012
Total Cost
$157,069
Indirect Cost
$53,734

  Institution

Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Moerel, Michelle; De Martino, Federico; Kemper, Valentin G et al. (2018) Sensitivity and specificity considerations for fMRI encoding, decoding, and mapping of auditory cortex at ultra-high field. Neuroimage 164:18-31
Plantinga, Birgit R; Temel, Yasin; Duchin, Yuval et al. (2018) Individualized parcellation of the subthalamic nucleus in patients with Parkinson's disease with 7T MRI. Neuroimage 168:403-411
Deelchand, Dinesh K; Kantarci, Kejal; Öz, Gülin (2018) Improved localization, spectral quality, and repeatability with advanced MRS methodology in the clinical setting. Magn Reson Med 79:1241-1250
Slopsema, Julia P; Peña, Edgar; Patriat, Remi et al. (2018) Clinical deep brain stimulation strategies for orientation-selective pathway activation. J Neural Eng 15:056029
Joers, James M; Deelchand, Dinesh K; Lyu, Tianmeng et al. (2018) Neurochemical abnormalities in premanifest and early spinocerebellar ataxias. Ann Neurol 83:816-829
Deelchand, Dinesh K; Auerbach, Edward J; Kobayashi, Naoharu et al. (2018) Transverse relaxation time constants of the five major metabolites in human brain measured in vivo using LASER and PRESS at 3 T. Magn Reson Med 79:1260-1265
Pisharady, Pramod Kumar; Sotiropoulos, Stamatios N; Duarte-Carvajalino, Julio M et al. (2018) Estimation of white matter fiber parameters from compressed multiresolution diffusion MRI using sparse Bayesian learning. Neuroimage 167:488-503
Olman, Cheryl A; Bao, Pinglei; Engel, Stephen A et al. (2018) Hemifield columns co-opt ocular dominance column structure in human achiasma. Neuroimage 164:59-66
Friedrich, Jillian; Kordasiewicz, Holly B; O'Callaghan, Brennon et al. (2018) Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles. JCI Insight 3:
Chu, Shu-Hsien; Parhi, Keshab K; Lenglet, Christophe (2018) Function-specific and Enhanced Brain Structural Connectivity Mapping via Joint Modeling of Diffusion and Functional MRI. Sci Rep 8:4741

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