The general aim of this proposal is to establish NINDS Institutional Center Core facilities that will augment the unique resources that exist at the Center for Magnetic Resonance Research (CMRR), University of Minnesota, for biomedical imaging, so as to maximize their utilization and impact on a large number of NINDS funded research projects on normal brain function and neurological disorders.
This aim i s based on the premise that developments in the last two decades have generated a plethora of magnetic resonance (MR) techniques, such as functional brain imaging (fMRI), neurochemical spectroscopy, perfusion imaging, diffusion imaging etc., that provide indispensable and otherwise unavailable measurement capabilities for studies of the brain in humans and in animal models of human diseased states. However, optimal use of these techniques requires advanced instrumentation, unique expertise, and complex auxiliary capabilities that include complementary measurements employing classical techniques (e.g. electrophysiology, and histology) and other imaging modalities such as PET. Access to these instrumentation and methodologies, especially at the cutting-edge, is virtually impossible in individual labs and requires interdisciplinary interactions in the area of spin-physics, RF engineering, signal and image processing, and brain sciences.
The aim of this grant is to provide this access within the cooperative, multidisciplinary, and interactive research environment of CMRR, so as to enrich the effectiveness of and promote new research directions in a large number of ongoing NINDS funded research projects.
|Hakkarainen, Hanne; Sierra, Alejandra; Mangia, Silvia et al. (2016) MRI relaxation in the presence of fictitious fields correlates with myelin content in normal rat brain. Magn Reson Med 75:161-8|
|McKay, Jessica; TkÃ¡Ä, Ivan (2016) Quantitative in vivo neurochemical profiling in humans: where are we now? Int J Epidemiol 45:1339-1350|
|Lu, Ming; Zhu, Xiao-Hong; Chen, Wei (2016) In vivo (31) P MRS assessment of intracellular NAD metabolites and NAD(+) /NADH redox state in human brain at 4 T. NMR Biomed 29:1010-7|
|Schallmo, Michael-Paul; Grant, Andrea N; Burton, Philip C et al. (2016) The effects of orientation and attention during surround suppression of small image features: A 7 Tesla fMRI study. J Vis 16:19|
|Kennedy, James T; Collins, Paul F; Luciana, Monica (2016) Higher Adolescent Body Mass Index Is Associated with Lower Regional Gray and White Matter Volumes and Lower Levels of Positive Emotionality. Front Neurosci 10:413|
|Pardon, Marie-Christine; Yanez Lopez, Maria; Yuchun, Ding et al. (2016) Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models. Sci Rep 6:19880|
|Lou, Song; Lepak, Victoria C; Eberly, Lynn E et al. (2016) Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress. Hum Mol Genet 25:2813-2826|
|Bernstein, Gail A; Mueller, Bryon A; Schreiner, Melinda Westlund et al. (2016) Abnormal striatal resting-state functional connectivity in adolescents with obsessive-compulsive disorder. Psychiatry Res 247:49-56|
|Qiu, Cheng; Burton, Philip C; Kersten, Daniel et al. (2016) Responses in early visual areas to contour integration are context dependent. J Vis 16:19|
|Farooq, Hamza; Xu, Junqian; Nam, Jung Who et al. (2016) Microstructure Imaging of Crossing (MIX) White Matter Fibers from diffusion MRI. Sci Rep 6:38927|
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