1. HIGH AND ULTRAHIGH FIELD IMAGE ACQUISITION AND ENGINEERING PI: Pierre-Francois van de Moortlele, PhD Core Aims The long-term goal of this core is to provide the means to enhance, broaden and accelerate a large array of ambitious neuroscience research projects that are increasingly utilizing high (3 and 4T) and ultrahigh (7T and above) field MR Imaging instruments and novel image acquisition and reconstruction techniques to investigate brain structure and function. Multiple studies have now amply demonstrated that MRI at higher magnetic fields can provide significant advantages in signal-to-noise ratio (SNR), spatial resolution, anatomical delineation, and anatomical and functional contrast. When combined with the appropriate imaging methods, these gains can be transformative in basic and translational neuroscience projects. However, access to such advanced capabilities by neuroscience researchers is virtually impossible outside the context of a collaborative and multidisciplinary relationship, especially (but not only) when instrumentation at the cutting-edge of the field, such as those operating at high (HF) and ultrahigh fields (UHF), and advanced, asof- yet commercially unavailable imaging methods are employed.
The aim of this core is to provide the necessary support and infrastructure that will allow a large community of NINDS funded investigators to utilize advanced imaging methodologies and instrumentation in CMRR where there exists a large parallel effort (funded by other sources) on instrumentation and methodology development.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
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Special Emphasis Panel (ZNS1-SRB-R)
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University of Minnesota Twin Cities
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Wilson, Sylia; Malone, Stephen M; Hunt, Ruskin H et al. (2017) Problematic alcohol use and hippocampal volume in a female sample: disentangling cause from consequence using a co-twin control study design. Psychol Med :1-12
Marja?ska, Ma?gorzata; McCarten, J Riley; Hodges, James et al. (2017) Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using 1H magnetic resonance spectroscopy at 7 T. Neuroscience 354:168-177
Cheong, Ian; Marja?ska, Ma?gorzata; Deelchand, Dinesh K et al. (2017) Ultra-High Field Proton MR Spectroscopy in Early-Stage Amyotrophic Lateral Sclerosis. Neurochem Res 42:1833-1844
Ramsay, Ian S; Nienow, Tasha M; MacDonald 3rd, Angus W (2017) Increases in Intrinsic Thalamocortical Connectivity and Overall Cognition Following Cognitive Remediation in Chronic Schizophrenia. Biol Psychiatry Cogn Neurosci Neuroimaging 2:355-362
Liu, Jiaen; Shao, Qi; Wang, Yicun et al. (2017) In vivo imaging of electrical properties of an animal tumor model with an 8-channel transceiver array at 7?T using electrical properties tomography. Magn Reson Med 78:2157-2169
Santoro, Roberta; Moerel, Michelle; De Martino, Federico et al. (2017) Reconstructing the spectrotemporal modulations of real-life sounds from fMRI response patterns. Proc Natl Acad Sci U S A 114:4799-4804
Zeydan, Burcu; Deelchand, Dinesh K; Tosakulwong, Nirubol et al. (2017) Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment: An sLASER Proton MR Spectroscopy and PiB-PET Study. J Neuroimaging 27:630-636
Joers, James M; Deelchand, Dinesh K; Kumar, Anjali et al. (2017) Measurement of Hypothalamic Glucose Under Euglycemia and Hyperglycemia by MRI at 3T. J Magn Reson Imaging 45:681-691
Deelchand, Dinesh K; Auerbach, Edward J; Marja?ska, Ma?gorzata (2017) Apparent diffusion coefficients of the five major metabolites measured in the human brain in vivo at 3T. Magn Reson Med :
Wang, Xiao; Zhu, Xiao-Hong; Zhang, Yi et al. (2017) A comparison study between the saturation-recovery-T1 and CASL MRI methods for quantitative CBF imaging. Magn Reson Imaging 37:179-186

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