The general aim of this proposal is to establish NINDS Institutional Center Core facilities that will augment the unique resources that exist at the Center for Magnetic Resonance Research (CMRR), University of Minnesota, for biomedical imaging, so as to maximize their utilization and impact on a large number of NINDS funded research projects on normal brain function and neurological disorders.
This aim i s based on the premise that developments in the last two decades have generated a plethora of magnetic resonance (MR) techniques, such as functional brain imaging (fMRI), neurochemical spectroscopy, perfusion imaging, diffusion imaging etc., that provide indispensable and otherwise unavailable measurement capabilities for studies of the brain in humans and in animal models of human diseased states. However, optimal use of these techniques requires advanced instrumentation, unique expertise, and complex auxiliary capabilities that include complementary measurements employing classical techniques (e.g. electrophysiology, and histology) and other imaging modalities such as PET. Access to these instrumentation and methodologies, especially at the cutting-edge, is virtually impossible in individual labs and requires interdisciplinary interactions in the area of spin-physics, RF engineering, signal and image processing, and brain sciences.
The aim of this grant is to provide this access within the cooperative, multidisciplinary, and interactive research environment of CMRR, so as to enrich the effectiveness of and promote new research directions in a large number of ongoing NINDS funded research projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS076408-03
Application #
8699282
Study Section
Special Emphasis Panel (ZNS1-SRB-R (59))
Program Officer
Talley, Edmund M
Project Start
2012-09-30
Project End
2017-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
3
Fiscal Year
2014
Total Cost
$946,758
Indirect Cost
$323,890
Name
University of Minnesota Twin Cities
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Moerel, Michelle; De Martino, Federico; Kemper, Valentin G et al. (2018) Sensitivity and specificity considerations for fMRI encoding, decoding, and mapping of auditory cortex at ultra-high field. Neuroimage 164:18-31
Plantinga, Birgit R; Temel, Yasin; Duchin, Yuval et al. (2018) Individualized parcellation of the subthalamic nucleus in patients with Parkinson's disease with 7T MRI. Neuroimage 168:403-411
Deelchand, Dinesh K; Kantarci, Kejal; Öz, Gülin (2018) Improved localization, spectral quality, and repeatability with advanced MRS methodology in the clinical setting. Magn Reson Med 79:1241-1250
Slopsema, Julia P; Peña, Edgar; Patriat, Remi et al. (2018) Clinical deep brain stimulation strategies for orientation-selective pathway activation. J Neural Eng 15:056029
Joers, James M; Deelchand, Dinesh K; Lyu, Tianmeng et al. (2018) Neurochemical abnormalities in premanifest and early spinocerebellar ataxias. Ann Neurol 83:816-829
Deelchand, Dinesh K; Auerbach, Edward J; Kobayashi, Naoharu et al. (2018) Transverse relaxation time constants of the five major metabolites in human brain measured in vivo using LASER and PRESS at 3 T. Magn Reson Med 79:1260-1265
Pisharady, Pramod Kumar; Sotiropoulos, Stamatios N; Duarte-Carvajalino, Julio M et al. (2018) Estimation of white matter fiber parameters from compressed multiresolution diffusion MRI using sparse Bayesian learning. Neuroimage 167:488-503
Olman, Cheryl A; Bao, Pinglei; Engel, Stephen A et al. (2018) Hemifield columns co-opt ocular dominance column structure in human achiasma. Neuroimage 164:59-66
Friedrich, Jillian; Kordasiewicz, Holly B; O'Callaghan, Brennon et al. (2018) Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles. JCI Insight 3:
Chu, Shu-Hsien; Parhi, Keshab K; Lenglet, Christophe (2018) Function-specific and Enhanced Brain Structural Connectivity Mapping via Joint Modeling of Diffusion and Functional MRI. Sci Rep 8:4741

Showing the most recent 10 out of 177 publications