Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff.
The specific aims for this year are the same as listed in the proposal for this grant, NIH COBRE 1 P30RR031154-01. The Center for Protein Structure and Function was established in October, 2000 with Phase I NIH COBRE Grant 1 P20 RR15569-01 and continued in September, 2005 with Phase II COBRE Grant 2 P20 RR015569-06. Protein structure and function is a central biomedical research area that has great potential for leading to improvements in human health. The Center supports thematically-linked multidisciplinary research projects involving junior faculty, mid-career faculty, and senior faculty with expertise in a broad range of techniques needed to study protein structure and function. The goals of the COBRE Center are to strengthen collaboration between investigators and allow them to develop promising new approaches to biomedical research in protein structure and function. The Center provides the junior investigators with the support and mentoring necessary to develop nationally competitive biomedical research careers, and attract funding through the normal NIH grant mechanism. The strategic plan for Phase III of our COBRE Center is (1) to maintain and strengthen the state-of-the-art COBRE research core facilities developed during phases I and II that are essential for the support of the research projects in the Center, and (2) to support research pilot projects and training components to sustain a collaborative, multidisciplinary research environment in protein structure and function.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Center Core Grants (P30)
Project #
5P30RR031154-02
Application #
8364928
Study Section
Special Emphasis Panel (ZRR1-RI-2 (01))
Project Start
2011-06-01
Project End
2012-05-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
2
Fiscal Year
2011
Total Cost
$109,378
Indirect Cost

  Institution

Name
University of Arkansas at Fayetteville
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
191429745
City
Fayetteville
State
AR
Country
United States
Zip Code
72701

  Publications

Paracha, Sadia; Hestekin, Christa (2016) Field amplified sample stacking of amyloid beta (1-42) oligomers using capillary electrophoresis. Biomicrofluidics 10:033105
Omogo, Benard; Gao, Feng; Bajwa, Pooja et al. (2016) Reducing Blinking in Small Core-Multishell Quantum Dots by Carefully Balancing Confinement Potential and Induced Lattice Strain: The ""Goldilocks"" Effect. ACS Nano 10:4072-82
Gao, Feng; Kight, Alicia D; Henderson, Rory et al. (2015) Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates. J Biol Chem 290:15462-74
Ponnapakkam, T; Katikaneni, R; Sakon, J et al. (2014) Treating osteoporosis by targeting parathyroid hormone to bone. Drug Discov Today 19:204-8
Katikaneni, Ranjitha; Ponnapakkam, Tulasi; Matsushita, Osamu et al. (2014) Treatment and prevention of chemotherapy-induced alopecia with PTH-CBD, a collagen-targeted parathyroid hormone analog, in a non-depilated mouse model. Anticancer Drugs 25:30-8
Pryor, N Elizabeth; Moss, Melissa A; Hestekin, Christa N (2014) Capillary electrophoresis for the analysis of the effect of sample preparation on early stages of A?1-40 aggregation. Electrophoresis 35:1814-20
Stratford Jr, Robert; Vu, Christopher; Sakon, Joshua et al. (2014) Pharmacokinetics in rats of a long-acting human parathyroid hormone-collagen binding domain peptide construct. J Pharm Sci 103:768-75
Bajpai, Geetika; Simmen, Rosalia C M; Stenken, Julie A (2014) In vivo microdialysis sampling of adipokines CCL2, IL-6, and leptin in the mammary fat pad of adult female rats. Mol Biosyst 10:806-12
Alwarsh, Sefat; Ayinuola, Kolawole; Dormi, Silvana S et al. (2013) Intercepting the Breslow intermediate via Claisen rearrangement: synthesis of complex tertiary alcohols without organometallic reagents. Org Lett 15:3-5
Horne, Alexandra J; Lessner, Daniel J (2013) Assessment of the oxidant tolerance of Methanosarcina acetivorans. FEMS Microbiol Lett 343:13-9

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