This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Co-Funded Instrumentation Core comprises a diverse group of three core capabilities, located at the Delaware Biotechnology Institute, that play a critical and enabling role to facilitate life sciences-based research at the University of Delaware and in the broader research community in the state. The facilities involved are: + The Bioimaging Center, a multi-user facility covering a comprehensive array of electron, confocal, light and scanning probe microscopy; + The Proteomics Center, offering services for measuring and quantifying protein expression profiles and for assessing post-translational modifications; + The Bioinformatics Center, which provides a range of computing resources. None of these facilities is managed by the COBRE;all are operated on a fee-for-service basis with additional institutional and infrastructure grant support. The support request by the COBRE provides fixed funding to each of the centers, allowing all COBRE investigators'labs extended use of the services of the centers.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-2 (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Delaware
Engineering (All Types)
Schools of Engineering
United States
Zip Code
Naranjo, Andrea N; McNeely, Patrick M; Katsaras, John et al. (2016) Impact of purification conditions and history on A2A adenosine receptor activity: The role of CHAPS and lipids. Protein Expr Purif 124:62-7
Choi, Yong Seok; Lee, Kelvin H (2016) Multiple reaction monitoring assay based on conventional liquid chromatography and electrospray ionization for simultaneous monitoring of multiple cerebrospinal fluid biomarker candidates for Alzheimer's disease. Arch Pharm Res 39:390-7
Naranjo, Andrea N; Chevalier, Amy; Cousins, Gregory D et al. (2015) Conserved disulfide bond is not essential for the adenosine A2A receptor: Extracellular cysteines influence receptor distribution within the cell and ligand-binding recognition. Biochim Biophys Acta 1848:603-14
Lee, Jung-Youn (2015) Plasmodesmata: a signaling hub at the cellular boundary. Curr Opin Plant Biol 27:133-40
Cui, Weier; Wang, Xu; Lee, Jung-Youn (2015) Drop-ANd-See: a simple, real-time, and noninvasive technique for assaying plasmodesmal permeability. Methods Mol Biol 1217:149-56
Modla, Shannon; Caplan, Jeffrey L; Czymmek, Kirk J et al. (2015) Localization of fluorescently tagged protein to plasmodesmata by correlative light and electron microscopy. Methods Mol Biol 1217:121-33
Min, Lie; Choe, Leila H; Lee, Kelvin H (2015) Improved protease digestion conditions for membrane protein detection. Electrophoresis 36:1690-8
Sager, Ross; Lee, Jung-Youn (2014) Plasmodesmata in integrated cell signalling: insights from development and environmental signals and stresses. J Exp Bot 65:6337-58
Suiter, Christopher L; Paramasivam, Sivakumar; Hou, Guangjin et al. (2014) Sensitivity gains, linearity, and spectral reproducibility in nonuniformly sampled multidimensional MAS NMR spectra of high dynamic range. J Biomol NMR 59:57-73
Young, Carissa L; Robinson, Anne S (2014) Protein folding and secretion: mechanistic insights advancing recombinant protein production in S. cerevisiae. Curr Opin Biotechnol 30:168-77

Showing the most recent 10 out of 45 publications