The mission of the OUHSC Baboon Research Resource is to provide resources that support biomedical and behavioral research requiring the baboon as the animal model. A vital part of this mission is the production of Specific Pathogen Free (SPF) baboons. Unique in the world, the OUHSC SPF baboon program is poised to provide an indispensable nonhuman primate resource for biomedical research. The goal of this program is to complete development of an active, self-supporting breeding colony of baboons that are free of all five known baboon herpes viruses, four retroviruses, as well as a number of additional viruses and parasites. The developing program is already providing some SPF baboons to NIH-funded biomedical research programs, but cannot meet the demand for these unique animals. To complete development of this national resource we will recruit an additional 150 infants over five years into the SPF program. The genetic diversity of the colony will be assessed and monitored to maximize its genetic diversity. During this final phase of colony development, we will continue to provide 20-30 SPF baboons per year to NIH-funded research programs. To keep the colony outbred genetic testing will be performed and evaluated. Several research projects will also be supported by this program with the aim of improving the resource. The long term objective is for the SPF baboon colony to be a stable, self-sustaining breeding colony that produces ~100 SPF baboons/year for use in NIH-funded biomedical research.

Public Health Relevance

Certain infectious agents can alter experimental results when they infect an animal used in research. Use of Specific Pathogen Free animals that are free of certain pathogens are preferred in biomedical research to avoid this problem. The SPF baboon program in Oklahoma is the only source for SPF baboons in the world and this grant will provide support for the development and maintenance of this colony.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
Application #
Study Section
Special Emphasis Panel (ZTR1-CM-6 (01))
Program Officer
Contreras, Miguel A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Oklahoma Health Sciences Center
Schools of Medicine
Oklahoma City
United States
Zip Code
Black, Darla; Ritchey, Jerry; Payton, Mark et al. (2014) Role of the virion host shutoff protein in neurovirulence of monkey B virus (Macacine herpesvirus 1). Virol Sin 29:274-83
Black, Darla; Ohsawa, Kazutaka; Tyler, Shaun et al. (2014) A single viral gene determines lethal cross-species neurovirulence of baboon herpesvirus HVP2. Virology 452-453:86-94
Willis, E L; Wolf, R F; White, G L et al. (2014) Age- and gender-associated changes in the concentrations of serum TGF-1*, DHEA-S and IGF-1 in healthy captive baboons (Papio hamadryas anubis). Gen Comp Endocrinol 195:21-7
Warfel, Jason M; Merkel, Tod J (2014) Reply to Domenech de Cell├Ęs et al.: Infection and transmission of pertussis in the baboon model. Proc Natl Acad Sci U S A 111:E718
Ohsawa, Kazutaka; Black, Darla; Ohsawa, Makiko et al. (2014) Genome sequence of a pathogenic isolate of monkey B virus (species Macacine herpesvirus 1). Arch Virol 159:2819-21
Zhou, Huidong; Iwase, Hayato; Wolf, Roman F et al. (2014) Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models? Xenotransplantation 21:287-90
Willis, Erin L; Eberle, Richard; Wolf, Roman F et al. (2014) The effects of age and cytomegalovirus on markers of inflammation and lymphocyte populations in captive baboons. PLoS One 9:e107167
Zhang, Weidong; Ahmad, Gul; Le, Loc et al. (2014) Longevity of Sm-p80-specific antibody responses following vaccination with Sm-p80 vaccine in mice and baboons and transplacental transfer of Sm-p80-specific antibodies in a baboon. Parasitol Res 113:2239-50
Warfel, Jason M; Papin, James F; Wolf, Roman F et al. (2014) Maternal and neonatal vaccination protects newborn baboons from pertussis infection. J Infect Dis 210:604-10
Karmakar, Souvik; Zhang, Weidong; Ahmad, Gul et al. (2014) Use of an Sm-p80-based therapeutic vaccine to kill established adult schistosome parasites in chronically infected baboons. J Infect Dis 209:1929-40

Showing the most recent 10 out of 11 publications