The mission of the OUHSC Baboon Research Resource is to provide resources that support biomedical and behavioral research requiring the baboon as the animal model. A vital part of this mission is the production of Specific Pathogen Free (SPF) baboons. Unique in the world, the OUHSC SPF baboon program is poised to provide an indispensable nonhuman primate resource for biomedical research. The goal of this program is to complete development of an active, self-supporting breeding colony of baboons that are free of all five known baboon herpes viruses, four retroviruses, as well as a number of additional viruses and parasites. The developing program is already providing some SPF baboons to NIH-funded biomedical research programs, but cannot meet the demand for these unique animals. To complete development of this national resource we will recruit an additional 150 infants over five years into the SPF program. The genetic diversity of the colony will be assessed and monitored to maximize its genetic diversity. During this final phase of colony development, we will continue to provide 20-30 SPF baboons per year to NIH-funded research programs. To keep the colony outbred genetic testing will be performed and evaluated. Several research projects will also be supported by this program with the aim of improving the resource. The long term objective is for the SPF baboon colony to be a stable, self-sustaining breeding colony that produces ~100 SPF baboons/year for use in NIH-funded biomedical research.

Public Health Relevance

Certain infectious agents can alter experimental results when they infect an animal used in research. Use of Specific Pathogen Free animals that are free of certain pathogens are preferred in biomedical research to avoid this problem. The SPF baboon program in Oklahoma is the only source for SPF baboons in the world and this grant will provide support for the development and maintenance of this colony.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
5P40OD010431-05
Application #
9205273
Study Section
Special Emphasis Panel (ZTR1-CM-6 (01))
Program Officer
Contreras, Miguel A
Project Start
2013-01-01
Project End
2017-12-31
Budget Start
2017-01-01
Budget End
2017-12-31
Support Year
5
Fiscal Year
2017
Total Cost
$691,247
Indirect Cost
$182,804
Name
University of Oklahoma Health Sciences Center
Department
Pathology
Type
Schools of Medicine
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104
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Iwase, Hayato; Liu, Hong; Schmelzer, Eva et al. (2017) Transplantation of hepatocytes from genetically engineered pigs into baboons. Xenotransplantation 24:
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Karmakar, Souvik; Zhang, Weidong; Ahmad, Gul et al. (2014) Use of an Sm-p80-based therapeutic vaccine to kill established adult schistosome parasites in chronically infected baboons. J Infect Dis 209:1929-40

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