The overall objective of the Caenorhabditis Genetics Center (CGC) is to promote research on the small metazoan Caenorhabditis elegans by acquiring, maintaining, and distributing genetically characterized nematode stocks. Researchers throughout the world use genetic stocks obtained from the CGC in diverse basic and applied research endeavors. Studies using this premier model organism have led to fundamental insights into basic biological mechanisms, including the genetic basis of programmed cell death, the discovery of microRNAs, and the mechanism of RNA interference in animals. The nematode has also proved important for understanding mechanisms of cancer progression and other diseases including Alzheimer's and Parkinson's, as well as for revealing basic mechanisms underlying human development. In addition, C. elegans serves as a key model for illuminating our understanding of parasitic nematodes with relevance to human and livestock health. As the sole general stock center for the nematode C. elegans, the CGC is an extremely important international research resource. The high demand for CGC strains reflects their great importance to the research community;currently more than 25,000 strains are distributed per year. The CGC curates C. elegans strains and distributes them upon request through an on-line ordering system. A new research component will be implemented to expand the activities of the CGC. The C. elegans genetic tool-kit will be enhanced through the generation of genetic tools to aid researchers in manipulations of lethal and sterile mutations.

Public Health Relevance

The Caenorhabditis Genetics Center (CGC) is the international repository and distribution center for the nematode C. elegans. Researchers throughout the world have used strains provided by the CGC to make important discoveries in diverse areas of biology, many with relevance to human health, including insights into neurodegenerative diseases, aging and cancer.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Chang, Michael
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Minnesota Twin Cities
Schools of Medicine
United States
Zip Code
Kuo, Cheng-Ju; Chen, Jenn-Wei; Chiu, Hao-Chieh et al. (2016) Mutation of the Enterohemorrhagic Escherichia coli Core LPS Biosynthesis Enzyme RfaD Confers Hypersusceptibility to Host Intestinal Innate Immunity In vivo. Front Cell Infect Microbiol 6:82
Liu, Yiyong; Sellegounder, Durai; Sun, Jingru (2016) Neuronal GPCR OCTR-1 regulates innate immunity by controlling protein synthesis in Caenorhabditis elegans. Sci Rep 6:36832
Wojtovich, Andrew P; Wei, Alicia Y; Sherman, Teresa A et al. (2016) Chromophore-Assisted Light Inactivation of Mitochondrial Electron Transport Chain Complex II in Caenorhabditis elegans. Sci Rep 6:29695
Noormohammadi, Alireza; Khodakarami, Amirabbas; Gutierrez-Garcia, Ricardo et al. (2016) Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan. Nat Commun 7:13649
Carr, David; Sanchez-Alvarez, Leticia; Imai, Janice H et al. (2016) A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans. PLoS One 11:e0157537
Munkácsy, Erin; Khan, Maruf H; Lane, Rebecca K et al. (2016) DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. PLoS Genet 12:e1006133
Turek, Michal; Besseling, Judith; Spies, Jan-Philipp et al. (2016) Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep. Elife 5:
Nichols, Annika L A; Meelkop, Ellen; Linton, Casey et al. (2016) The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons. Cell Rep 14:1673-83
Liro, Malgorzata J; Rose, Lesilee S (2016) Mitotic Spindle Positioning in the EMS Cell of Caenorhabditis elegans Requires LET-99 and LIN-5/NuMA. Genetics :
Machovina, Tyler S; Mainpal, Rana; Daryabeigi, Anahita et al. (2016) A Surveillance System Ensures Crossover Formation in C. elegans. Curr Biol 26:2873-2884

Showing the most recent 10 out of 812 publications