The overall objective of the Caenorhabditis Genetics Center (CGC) is to promote research on the small metazoan Caenorhabditis elegans by acquiring, maintaining, and distributing genetically characterized nematode stocks. Researchers throughout the world use genetic stocks obtained from the CGC in diverse basic and applied research endeavors. Studies using this premier model organism have led to fundamental insights into basic biological mechanisms, including the genetic basis of programmed cell death, the discovery of microRNAs, and the mechanism of RNA interference in animals. The nematode has also proved important for understanding mechanisms of cancer progression and other diseases including Alzheimer's and Parkinson's, as well as for revealing basic mechanisms underlying human development. In addition, C. elegans serves as a key model for illuminating our understanding of parasitic nematodes with relevance to human and livestock health. As the sole general stock center for the nematode C. elegans, the CGC is an extremely important international research resource. The high demand for CGC strains reflects their great importance to the research community;currently more than 25,000 strains are distributed per year. The CGC curates C. elegans strains and distributes them upon request through an on-line ordering system. A new research component will be implemented to expand the activities of the CGC. The C. elegans genetic tool-kit will be enhanced through the generation of genetic tools to aid researchers in manipulations of lethal and sterile mutations.

Public Health Relevance

The Caenorhabditis Genetics Center (CGC) is the international repository and distribution center for the nematode C. elegans. Researchers throughout the world have used strains provided by the CGC to make important discoveries in diverse areas of biology, many with relevance to human health, including insights into neurodegenerative diseases, aging and cancer.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
3P40OD010440-03S1
Application #
8920181
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Harding, John D
Project Start
2012-09-01
Project End
2017-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
3
Fiscal Year
2014
Total Cost
$20,000
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Genetics
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Tsukamoto, Tatsuya; Gearhart, Micah D; Spike, Caroline A et al. (2017) LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Genetics 206:2007-2039
Jiang, Hongbing; Chen, Kevin; Sandoval, Luis E et al. (2017) An Evolutionarily Conserved Pathway Essential for Orsay Virus Infection of Caenorhabditis elegans. MBio 8:
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Fouad, Anthony D; Pu, Shelley H; Teng, Shelly et al. (2017) Quantitative Assessment of Fat Levels in Caenorhabditis elegans Using Dark Field Microscopy. G3 (Bethesda) 7:1811-1818
Palamiuc, Lavinia; Noble, Tallie; Witham, Emily et al. (2017) A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism. Nat Commun 8:14237
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Fradin, Hélène; Kiontke, Karin; Zegar, Charles et al. (2017) Genome Architecture and Evolution of a Unichromosomal Asexual Nematode. Curr Biol 27:2928-2939.e6
Kim, Sharon; Twigg, Stephen R F; Scanlon, Victoria A et al. (2017) Localized TWIST1 and TWIST2 basic domain substitutions cause four distinct human diseases that can be modeled in Caenorhabditis elegans. Hum Mol Genet 26:2118-2132
Yoon, Dong Suk; Alfhili, Mohammad A; Friend, Kyle et al. (2017) MPK-1/ERK regulatory network controls the number of sperm by regulating timing of sperm-oocyte switch in C. elegans germline. Biochem Biophys Res Commun 491:1077-1082

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