The overall objective of the Caenorhabditis Genetics Center (CGC) is to promote research on the small metazoan Caenorhabditis elegans by acquiring, maintaining, and distributing genetically characterized nematode stocks. Researchers throughout the world use genetic stocks obtained from the CGC in diverse basic and applied research endeavors. Studies using this premier model organism have led to fundamental insights into basic biological mechanisms, including the genetic basis of programmed cell death, the discovery of microRNAs, and the mechanism of RNA interference in animals. The nematode has also proved important for understanding mechanisms of cancer progression and other diseases including Alzheimer's and Parkinson's, as well as for revealing basic mechanisms underlying human development. In addition, C. elegans serves as a key model for illuminating our understanding of parasitic nematodes with relevance to human and livestock health. As the sole general stock center for the nematode C. elegans, the CGC is an extremely important international research resource. The high demand for CGC strains reflects their great importance to the research community;currently more than 25,000 strains are distributed per year. The CGC curates C. elegans strains and distributes them upon request through an on-line ordering system. A new research component will be implemented to expand the activities of the CGC. The C. elegans genetic tool-kit will be enhanced through the generation of genetic tools to aid researchers in manipulations of lethal and sterile mutations.

Public Health Relevance

The Caenorhabditis Genetics Center (CGC) is the international repository and distribution center for the nematode C. elegans. Researchers throughout the world have used strains provided by the CGC to make important discoveries in diverse areas of biology, many with relevance to human health, including insights into neurodegenerative diseases, aging and cancer.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
3P40OD010440-03S1
Application #
8920181
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Harding, John D
Project Start
2012-09-01
Project End
2017-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
3
Fiscal Year
2014
Total Cost
$20,000
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Genetics
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
He, Baoshen; Zhang, Jingjing; Wang, Yanli et al. (2018) Identification of cytochrome b5 CYTB-5.1 and CYTB-5.2 in C. elegans; evidence for differential regulation of SCD. Biochim Biophys Acta Mol Cell Biol Lipids 1863:235-246
White, Corin V; Herman, Michael A (2018) Transcriptomic, Functional, and Network Analyses Reveal Novel Genes Involved in the Interaction Between Caenorhabditis elegans and Stenotrophomonas maltophilia. Front Cell Infect Microbiol 8:266
Mazzochette, E A; Nekimken, A L; Loizeau, F et al. (2018) The tactile receptive fields of freely moving Caenorhabditis elegans nematodes. Integr Biol (Camb) 10:450-463
Seo, Yonghak; Kingsley, Samuel; Walker, Griffin et al. (2018) Metabolic shift from glycogen to trehalose promotes lifespan and healthspan in Caenorhabditis elegans. Proc Natl Acad Sci U S A 115:E2791-E2800
Kim, Sungjin; Sieburth, Derek (2018) Sphingosine Kinase Regulates Neuropeptide Secretion During the Oxidative Stress-Response Through Intertissue Signaling. J Neurosci 38:8160-8176
Ni, Julie Zhouli; Kalinava, Natallia; Mendoza, Sofia Galindo et al. (2018) The spatial and temporal dynamics of nuclear RNAi-targeted retrotransposon transcripts in Caenorhabditis elegans. Development 145:
Lanzo, Ambra; Safratowich, Bryan D; Kudumala, Sirisha R et al. (2018) Silencing of Syntaxin 1A in the Dopaminergic Neurons Decreases the Activity of the Dopamine Transporter and Prevents Amphetamine-Induced Behaviors in C. elegans. Front Physiol 9:576
Ranawade, Ayush; Mallick, Avijit; Gupta, Bhagwati P (2018) PRY-1/Axin signaling regulates lipid metabolism in Caenorhabditis elegans. PLoS One 13:e0206540
Song, Myungchul; Song, Kyunghee; Kim, Sunghee et al. (2018) Caenorhabditis elegans BRICHOS Domain-Containing Protein C09F5.1 Maintains Thermotolerance and Decreases Cytotoxicity of A?42 by Activating the UPR. Genes (Basel) 9:
Spensley, Mark; Del Borrello, Samantha; Pajkic, Djina et al. (2018) Acute Effects of Drugs on Caenorhabditis elegans Movement Reveal Complex Responses and Plasticity. G3 (Bethesda) 8:2941-2952

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