The National Natural Toxins Research Center (NNTRC), a component of Texas A&M University-Kingsville (TAMUK), is a unique animal and biological material resource Center organized to support basic and translational research on venomous snakes and their venoms. The NNTRC is dedicated to the advancement in the understanding of the therapeutic value of venom molecules and to the training of research scientists in the field of toxinology. Since its inception in 1978 the NNTRC has grown to become the only federally funded viper resource center in the U.S. providing high quality venom and snake-related research materials to national and international biomedical and biological research programs. The goal of the NNTRC is to provide native venoms, purified venom components, cDNA clones, and recombinant venom proteins of the highest quality to support biomedical research. To achieve this goal the NNTRC will address the following Specific Aims:
Aim 1 : To operate the National Natural Toxins Research Center as a resource Center that provides high quality venom and products that support biological and biomedical research for national and international research programs.
Aim 2 : To develop and expand the collection of the snakes, specialized services, education and outreach programs to support growth of venom-related research in the U.S.
Aim 3 : To support a state-of-the-art applied research program using high-throughput genomic, proteomic, recombinant DNA and screening technologies that will support an information-based approach to the discovery of snake venom components with potential therapeutic and/or diagnostic applications. In the preceding five years the NNTRC has made significant contributions to the advancement of both academic research and the commercial development of pharmaceutical and anti-venom therapeutics. The resources of the NNTRC have been applied to research in a wide range of disciplines and therapeutic areas ranging from phylogenetic studies on venom evolution to translational research on nociception and hemostasis, research that has been supported by multiple NIH ICs, the NSF and national and international research agencies and foundations. In addition to its role as a national resource for venom research and as a Center of toxinology research, the NNTRC has also played an important role in providing opportunities for underrepresented students and faculty to gain training in the field of biomedical research.

Public Health Relevance

The NNTRC is dedicated to the support of scientists and researchers engaged in the search for new treatments for disease based on the properties of molecules found in the snake venoms. Discoveries made with the support of the NNTRC are contributing to advances in the understanding of basic cellular processes as well as the discovery of new approaches for the treatment of cancer and blood clotting diseases.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
2P40OD010960-11A1
Application #
8666312
Study Section
Special Emphasis Panel (ZOD1-CM-8 (01))
Program Officer
Chang, Michael
Project Start
2003-04-15
Project End
2019-02-28
Budget Start
2014-06-01
Budget End
2015-02-28
Support Year
11
Fiscal Year
2014
Total Cost
$502,963
Indirect Cost
$138,497
Name
Texas A&M University-Kingsville
Department
Biochemistry
Type
Other Domestic Higher Education
DUNS #
868154089
City
Kingsville
State
TX
Country
United States
Zip Code
78363
Dowell, Noah L; Giorgianni, Matt W; Kassner, Victoria A et al. (2016) The Deep Origin and Recent Loss of Venom Toxin Genes in Rattlesnakes. Curr Biol 26:2434-45
Margres, Mark J; Walls, Robert; Suntravat, Montamas et al. (2016) Functional characterizations of venom phenotypes in the eastern diamondback rattlesnake (Crotalus adamanteus) and evidence for expression-driven divergence in toxic activities among populations. Toxicon 119:28-38
Vivas, Jeilyn; Ibarra, Carlos; Salazar, Ana M et al. (2016) Purification and characterization of tenerplasminin-1, a serine peptidase inhibitor with antiplasmin activity from the coral snake (Micrurus tener tener) venom. Comp Biochem Physiol C Toxicol Pharmacol 179:107-15
Cantú Jr, Esteban; Mallela, Sahiti; Nyguen, Matthew et al. (2016) The binding effectiveness of anti-rdisintegrin polyclonal antibodies against disintegrins and PII and PIII metalloproteases: An immunological survey of type A, B and A+B venoms from Mohave rattlesnakes. Comp Biochem Physiol C Toxicol Pharmacol :
Komives, Claire F; Sancheza, Elda E; Rathore, Anurag S et al. (2016) Opossum peptide that can neutralize rattlesnake venom is expressed in Escherichia coli. Biotechnol Prog :
Ramos, Carla J; Gutierrez, Daniel A; Aranda, Ana S et al. (2016) Functional characterization of six aspartate (D) recombinant mojastin mutants (r-Moj): A second aspartate amino acid carboxyl to the RGD in r-Moj-D_ peptides is not sufficient to induce apoptosis of SK-Mel-28 cells. Toxicon 118:36-42
Suntravat, Montamas; Helmke, Thomas J; Atphaisit, Chairat et al. (2016) Expression, purification, and analysis of three recombinant ECD disintegrins (r-colombistatins) from P-III class snake venom metalloproteinases affecting platelet aggregation and SK-MEL-28 cell adhesion. Toxicon 122:43-49
Gutierrez, Daniel A; Aranda, Ana S; Carrillo, David A R et al. (2016) Functional analysis of four single (RGDWL, RGDWM, RGDWP, RGDMN) and two double (RGDNM, RGDMP) mutants: The importance of methionine (M) in the functional potency of recombinant mojastin (r-Moj). Toxicon 124:1-7
Suntravat, Montamas; Uzcategui, Néstor L; Atphaisit, Chairat et al. (2016) Gene expression profiling of the venom gland from the Venezuelan mapanare (Bothrops colombiensis) using expressed sequence tags (ESTs). BMC Mol Biol 17:7
Lucena, Sara; Castro, Roberto; Lundin, Courtney et al. (2015) Inhibition of pancreatic tumoral cells by snake venom disintegrins. Toxicon 93:136-43

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