The OUHSC Baboon Resource Program continues to serves as a national source of baboons for NIH supported biomedical and behavioral research. Over the last four years we have provided 582 baboons to 23 Institutions outside the University of Oklahoma Health Sciences Center. We have also provided 110 baboons over the last four years for the developing OUHSC Baboon Specific Pathogen Free (SPF) baboon program. This SPF colony is unique and is the only known NIH baboon colony that is negative for 13 endogenous viruses including all five known baboon herpes viruses, four retroviruses, plus four other baboon viruses and the most common baboon parasites. We continue to make significant progress toward self-sufficiency as the program income provides almost 50% of the support of the baboon research resource program. Significant progress has been made in our infrastructure with the completion of the new state of the art 6.5 million dollar, 18,000 square foot Baboon SPF building. Our collaboration with the Oklahoma State University Center for Veterinary Health Sciences (OSUHSC) (College of Veterinary Medicine) continues to produce significant research resource related research. This application has a significantly stronger behavioral and genetic program with the addition of a PhD level genetic behaviorist (John Ely, PhD). We are now performing in house viral diagnostics with the addition of a full time PhD level Virologist (James Papin, PhD). Recently we have added a full time Veterinary Immunologist to our Comparative Medicine Faculty (Sunil Joshi, DVM, PhD). These three full time research and diagnostic faculty significantly strengthens our diagnostic and research expertise in behavior, genonomics, virology, and immunology. The OUHSC Baboon Research Resource program continues to attract more veterinary student preceptors. Over the last four years we have had veterinary student preceptors and visiting summer students from seven veterinary schools. We continue to host a summer visit and tour for NIH T 35 students from, Oklahoma State University, University of Missouri, and Kansas State University. The OUHSC Baboon Research Resource continues to serve as a national source for biomedical, and behavior research.

Public Health Relevance

The OUHSC Baboon Research Resource is one of two NIH baboon programs supported by the NIH. We support both conventional and specific pathogen free baboons to NIH supported investigators nationally. The baboon ranks third among the number of non-human primates used in biomedical and behavioral research in the United States. An OVID Medline search revealed that over the last five years 1,028 scientific publications utilized the baboons as the animal model.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
2P40OD010988-16
Application #
8476043
Study Section
Special Emphasis Panel (ZTR1-CM-6 (01))
Program Officer
Contreras, Miguel A
Project Start
1998-09-01
Project End
2018-05-31
Budget Start
2013-07-02
Budget End
2014-05-31
Support Year
16
Fiscal Year
2013
Total Cost
$1,298,679
Indirect Cost
$374,134
Name
University of Oklahoma Health Sciences Center
Department
Pathology
Type
Schools of Medicine
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Willis, E L; Wolf, R F; White, G L et al. (2014) Age- and gender-associated changes in the concentrations of serum TGF-1*, DHEA-S and IGF-1 in healthy captive baboons (Papio hamadryas anubis). Gen Comp Endocrinol 195:21-7
Warfel, Jason M; Merkel, Tod J (2014) Reply to Domenech de Cell├Ęs et al.: Infection and transmission of pertussis in the baboon model. Proc Natl Acad Sci U S A 111:E718
Ohsawa, Kazutaka; Black, Darla; Ohsawa, Makiko et al. (2014) Genome sequence of a pathogenic isolate of monkey B virus (species Macacine herpesvirus 1). Arch Virol 159:2819-21
Stuck, Michael W; Conley, Shannon M; Shaw, Ryan A et al. (2014) Electrophysiological characterization of rod and cone responses in the baboon nonhuman primate model. Adv Exp Med Biol 801:67-73
Merkel, Tod J; Halperin, Scott A (2014) Nonhuman primate and human challenge models of pertussis. J Infect Dis 209 Suppl 1:S20-3
Zhou, Huidong; Iwase, Hayato; Wolf, Roman F et al. (2014) Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models? Xenotransplantation 21:287-90
Tran, L; Greenwood-Van Meerveld, B (2014) In a non-human primate model, aging disrupts the neural control of intestinal smooth muscle contractility in a region-specific manner. Neurogastroenterol Motil 26:410-8
Iwase, Hayato; Ezzelarab, Mohamed B; Ekser, Burcin et al. (2014) The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options. Xenotransplantation 21:201-20
Willis, Erin L; Eberle, Richard; Wolf, Roman F et al. (2014) The effects of age and cytomegalovirus on markers of inflammation and lymphocyte populations in captive baboons. PLoS One 9:e107167
Zhang, Weidong; Ahmad, Gul; Le, Loc et al. (2014) Longevity of Sm-p80-specific antibody responses following vaccination with Sm-p80 vaccine in mice and baboons and transplacental transfer of Sm-p80-specific antibodies in a baboon. Parasitol Res 113:2239-50

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