The OUHSC Baboon Resource Program continues to serves as a national source of baboons for NIH supported biomedical and behavioral research. Over the last four years we have provided 582 baboons to 23 Institutions outside the University of Oklahoma Health Sciences Center. We have also provided 110 baboons over the last four years for the developing OUHSC Baboon Specific Pathogen Free (SPF) baboon program. This SPF colony is unique and is the only known NIH baboon colony that is negative for 13 endogenous viruses including all five known baboon herpes viruses, four retroviruses, plus four other baboon viruses and the most common baboon parasites. We continue to make significant progress toward self-sufficiency as the program income provides almost 50% of the support of the baboon research resource program. Significant progress has been made in our infrastructure with the completion of the new state of the art 6.5 million dollar, 18,000 square foot Baboon SPF building. Our collaboration with the Oklahoma State University Center for Veterinary Health Sciences (OSUHSC) (College of Veterinary Medicine) continues to produce significant research resource related research. This application has a significantly stronger behavioral and genetic program with the addition of a PhD level genetic behaviorist (John Ely, PhD). We are now performing in house viral diagnostics with the addition of a full time PhD level Virologist (James Papin, PhD). Recently we have added a full time Veterinary Immunologist to our Comparative Medicine Faculty (Sunil Joshi, DVM, PhD). These three full time research and diagnostic faculty significantly strengthens our diagnostic and research expertise in behavior, genonomics, virology, and immunology. The OUHSC Baboon Research Resource program continues to attract more veterinary student preceptors. Over the last four years we have had veterinary student preceptors and visiting summer students from seven veterinary schools. We continue to host a summer visit and tour for NIH T 35 students from, Oklahoma State University, University of Missouri, and Kansas State University. The OUHSC Baboon Research Resource continues to serve as a national source for biomedical, and behavior research.

Public Health Relevance

The OUHSC Baboon Research Resource is one of two NIH baboon programs supported by the NIH. We support both conventional and specific pathogen free baboons to NIH supported investigators nationally. The baboon ranks third among the number of non-human primates used in biomedical and behavioral research in the United States. An OVID Medline search revealed that over the last five years 1,028 scientific publications utilized the baboons as the animal model.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
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Study Section
Special Emphasis Panel (ZTR1-CM-6 (01))
Program Officer
Contreras, Miguel A
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University of Oklahoma Health Sciences Center
Schools of Medicine
Oklahoma City
United States
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Iwase, Hayato; Ekser, Burcin; Hara, Hidetaka et al. (2016) Thyroid hormone: relevance to xenotransplantation. Xenotransplantation 23:293-9
Boosalis, Michael S; Sangerman, Jose I; White, Gary L et al. (2015) Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice. PLoS One 10:e0144660
Iwase, H; Ekser, B; Satyananda, V et al. (2015) Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs. Transpl Immunol 32:99-108
Iwase, Hayato; Ekser, Burcin; Zhou, Huidong et al. (2015) Further evidence for sustained systemic inflammation in xenograft recipients (SIXR). Xenotransplantation 22:399-405
Ezzelarab, Mohamed B; Ekser, Burcin; Azimzadeh, Agnes et al. (2015) Systemic inflammation in xenograft recipients precedes activation of coagulation. Xenotransplantation 22:32-47
Nguyen, Annalee W; Wagner, Ellen K; Laber, Joshua R et al. (2015) A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough. Sci Transl Med 7:316ra195
Warfel, Jason M; Merkel, Tod J (2014) Reply to Domenech de Cellès et al.: Infection and transmission of pertussis in the baboon model. Proc Natl Acad Sci U S A 111:E718
Ohsawa, Kazutaka; Black, Darla; Ohsawa, Makiko et al. (2014) Genome sequence of a pathogenic isolate of monkey B virus (species Macacine herpesvirus 1). Arch Virol 159:2819-21
Merkel, Tod J; Halperin, Scott A (2014) Nonhuman primate and human challenge models of pertussis. J Infect Dis 209 Suppl 1:S20-3
Iwase, Hayato; Ezzelarab, Mohamed B; Ekser, Burcin et al. (2014) The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options. Xenotransplantation 21:201-20

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