Zebrafish is a premiere organism to study vertebrate development, physiology, behavior, genetics and disease. Powerful techniques allow efficient generation and recovery of zebrafish mutations affecting genes that regulate developmental patterning, organogenesis, physiology and behavior. Recent advances make it easy to study gene function in transgenic zebrafish and with antisense oligonucleotides. The functions of many, if not most of these genes are conserved among vertebrate groups. Thus, analysis of zebrafish mutations provides insights into gene function in other vertebrates, including humans. The Zebrafish International Resource Center has been established as a repository that provides animals, materials and services to the research community. This proposal seeks continued funding 1) to provide a centralized repository for zebrafish genetic stocks and research materials, 2) to provide consultation and pathology services, and 3) to develop improved zebrafish husbandry methods. These materials, services and information will be made widely available to the research community.

Public Health Relevance

The Zebrafish International Resource Genter 1) provides a centralized repository for zebrafish genetic stocks and research materials, 2) provides consultation and pathology services, and 3) develops improved zebrafish husbandry methods. These materials, services and information will be made widely available to the research community.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
3P40OD011021-16S1
Application #
8854172
Study Section
Special Emphasis Panel (ZOD1-CM-6 (01))
Program Officer
Chang, Michael
Project Start
1998-05-01
Project End
2018-04-30
Budget Start
2014-07-09
Budget End
2015-04-30
Support Year
16
Fiscal Year
2014
Total Cost
$245,795
Indirect Cost
Name
University of Oregon
Department
Other Basic Sciences
Type
Organized Research Units
DUNS #
948117312
City
Eugene
State
OR
Country
United States
Zip Code
97403
Chow, F W; Xue, L; Kent, M L (2016) Retrospective study of the prevalence of Pseudoloma neurophilia shows male sex bias in zebrafish Danio rerio (Hamilton-Buchanan). J Fish Dis 39:367-70
Murray, Katrina N; Peterson, Tracy S (2015) Pathology in practice. P tomentosa infection in zebrafish. J Am Vet Med Assoc 246:201-3
Paquette, Colleen E; Kent, Michael L; Peterson, Tracy S et al. (2015) Immunohistochemical characterization of intestinal neoplasia in zebrafish Danio rerio indicates epithelial origin. Dis Aquat Organ 116:191-7
Spagnoli, Sean; Xue, Lan; Kent, Michael L (2015) The common neural parasite Pseudoloma neurophilia is associated with altered startle response habituation in adult zebrafish (Danio rerio): Implications for the zebrafish as a model organism. Behav Brain Res 291:351-60
Spagnoli, Sean Thomas; Xue, Lan; Murray, Katrina N et al. (2015) Pseudoloma neurophilia: a retrospective and descriptive study of nervous system and muscle infections, with new implications for pathogenesis and behavioral phenotypes. Zebrafish 12:189-201
Whipps, Christopher M; Murray, Katrina N; Kent, Michael L (2015) Occurrence of a myxozoan parasite Myxidium streisingeri n. sp. in laboratory zebrafish Danio rerio. J Parasitol 101:86-90
Cooper, T K; Murray, K N; Spagnoli, S et al. (2015) Primary intestinal and vertebral chordomas in laboratory zebrafish (Danio rerio). Vet Pathol 52:388-92
Whipps, Christopher M; Moss, Larry G; Sisk, Dana M et al. (2014) Detection of autofluorescent Mycobacterium chelonae in living zebrafish. Zebrafish 11:76-82