This grant will provide continued NIH support to maintain the Caribbean Primate Research Center (CPRC). The CPRC consists of four integrated facilities: (1) Cayo Santiago, a unique free-ranging island colony of Indian-origin rhesus monkeys (Macaca mulatta);(2) the Sabana Seca Field Station, the CPRC's headquarters located 10 miles outside of San Juan, that houses rhesus monkeys derived from the Cayo Santiago colony in various outdoor configurations for biomedical and behavioral studies that are not feasible on free-ranging animals;(3) the Laboratory of Virology and Genetics (LVG), located on the Medical Sciences Campus (MSC), in San Juan;and (4) the Laboratory of Primate Morphology and Genetics (LPMG), which is also located on the MSC, and houses the CPRC Skeletal Collections, unique assemblages of nonhuman primate skeletons for genetic, developmental, pathological and anatomical research. As described in this proposal, CPRC is organized into four complementary and integrated divisions: Primate Resources, Virology and Genetics, Behavior and Neurosciences, and Primate Morphology &Genetics. Funds are requested in this application only to maintain CPRC basic infrastructure of Primate Resources, which are used to support numerous research projects across the United States. This core grant will also allow CPRC to seek additional support to launch collaborative research projects with mainland and international investigators. With continued NIH support, the CPRC will remain a significant national research resource and will be able to provide healthy Indian-origin rhesus monkeys of defined genetic and virological background to NIH-sponsored research programs.

Public Health Relevance

The CPRC continues to be a platform that supports numerous PHS-sponsored research projects throughout USA. The Center provides Indian-origin rhesus monkeys which serve as models for the development of effective treatments against human diseases. With the needed NCRR support to this grant, the CPRC will continue to be one of the largest nationwide providers of SPF and of conventional rhesus monkeys required for AIDS and for other biomedical research projects and a valuable research resource needed for behavioral and biomedical studies.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
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National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Contreras, Miguel A
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University of Puerto Rico Med Sciences
Other Domestic Higher Education
San Juan
United States
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Kessler, Matthew J; Hernández Pacheco, Raisa; Rawlins, Richard G et al. (2015) Long-term effects of tetanus toxoid inoculation on the demography and life expectancy of the Cayo Santiago rhesus macaques. Am J Primatol 77:211-21
Messer, William B; de Alwis, Ruklanthi; Yount, Boyd L et al. (2014) Dengue virus envelope protein domain I/II hinge determines long-lived serotype-specific dengue immunity. Proc Natl Acad Sci U S A 111:1939-44
Pfefferle, Dana; Kazem, Anahita J N; Brockhausen, Ralf R et al. (2014) Monkeys spontaneously discriminate their unfamiliar paternal kin under natural conditions using facial cues. Curr Biol 24:1806-10
Pfefferle, Dana; Ruiz-Lambides, Angelina V; Widdig, Anja (2014) Female rhesus macaques discriminate unfamiliar paternal sisters in playback experiments: support for acoustic phenotype matching. Proc Biol Sci 281:20131628
Anglero-Rodriguez, Yesseinia I; Pantoja, Petraleigh; Sariol, Carlos A (2014) Dengue virus subverts the interferon induction pathway via NS2B/3 protease-I*B kinase epsilon interaction. Clin Vaccine Immunol 21:29-38
Mandalaywala, Tara M; Parker, Karen J; Maestripieri, Dario (2014) Early experience affects the strength of vigilance for threat in rhesus monkey infants. Psychol Sci 25:1893-902
Abdulhaqq, Shaheed A; Martinez, Melween I; Kang, Guobin et al. (2014) Serial cervicovaginal exposures with replication-deficient SIVsm induce higher dendritic cell (pDC) and CD4+ T-cell infiltrates not associated with prevention but a more severe SIVmac251 infection of rhesus macaques. J Acquir Immune Defic Syndr 65:405-13
Hernández-Pacheco, Raisa; Rawlins, Richard G; Kessler, Matthew J et al. (2013) Demographic variability and density-dependent dynamics of a free-ranging rhesus macaque population. Am J Primatol 75:1152-64
Venkataraman, Vivek V; Rolian, Campbell; Gordon, Adam D et al. (2013) A resampling approach and implications for estimating the phalangeal index from unassociated hand bones in fossil primates. Am J Phys Anthropol 151:280-9
Langos, Doreen; Kulik, Lars; Mundry, Roger et al. (2013) The impact of paternity on male-infant association in a primate with low paternity certainty. Mol Ecol 22:3638-51

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