This grant will provide continued NIH support to maintain the Caribbean Primate Research Center (CPRC). The CPRC consists of four integrated facilities: (1) Cayo Santiago, a unique free-ranging island colony of Indian-origin rhesus monkeys (Macaca mulatta);(2) the Sabana Seca Field Station, the CPRC's headquarters located 10 miles outside of San Juan, that houses rhesus monkeys derived from the Cayo Santiago colony in various outdoor configurations for biomedical and behavioral studies that are not feasible on free-ranging animals;(3) the Laboratory of Virology and Genetics (LVG), located on the Medical Sciences Campus (MSC), in San Juan;and (4) the Laboratory of Primate Morphology and Genetics (LPMG), which is also located on the MSC, and houses the CPRC Skeletal Collections, unique assemblages of nonhuman primate skeletons for genetic, developmental, pathological and anatomical research. As described in this proposal, CPRC is organized into four complementary and integrated divisions: Primate Resources, Virology and Genetics, Behavior and Neurosciences, and Primate Morphology &Genetics. Funds are requested in this application only to maintain CPRC basic infrastructure of Primate Resources, which are used to support numerous research projects across the United States. This core grant will also allow CPRC to seek additional support to launch collaborative research projects with mainland and international investigators. With continued NIH support, the CPRC will remain a significant national research resource and will be able to provide healthy Indian-origin rhesus monkeys of defined genetic and virological background to NIH-sponsored research programs.

Public Health Relevance

(provided by applicant): The CPRC continues to be a platform that supports numerous PHS-sponsored research projects throughout USA. The Center provides Indian-origin rhesus monkeys which serve as models for the development of effective treatments against human diseases. With the needed NCRR support to this grant, the CPRC will continue to be one of the largest nationwide providers of SPF and of conventional rhesus monkeys required for AIDS and for other biomedical research projects and a valuable research resource needed for behavioral and biomedical studies.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
2P40RR003640-24A1
Application #
8016743
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Harding, John D
Project Start
1987-04-15
Project End
2015-11-30
Budget Start
2011-01-01
Budget End
2011-11-30
Support Year
24
Fiscal Year
2011
Total Cost
$2,220,984
Indirect Cost
Name
University of Puerto Rico Med Sciences
Department
Type
Other Domestic Higher Education
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
00936
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Zhdanova, Irina V; Rogers, Jeffrey; González-Martínez, Janis et al. (2016) The ticking clock of Cayo Santiago macaques and its implications for understanding human circadian rhythm disorders. Am J Primatol 78:117-26
Kessler, Matthew J; Wang, Qian; Cerroni, Antonietta M et al. (2016) Long-term effects of castration on the skeleton of male rhesus monkeys (Macaca mulatta). Am J Primatol 78:152-66
Rosati, Alexandra G; Santos, Laurie R (2016) Spontaneous Metacognition in Rhesus Monkeys. Psychol Sci 27:1181-91
Wang, Qian; Turnquist, Jean E; Kessler, Matthew J (2016) Free-ranging Cayo Santiago rhesus monkeys (Macaca mulatta): III. Dental eruption patterns and dental pathology. Am J Primatol 78:127-42

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