This grant will provide continued NIH support to maintain the Caribbean Primate Research Center (CPRC). The CPRC consists of four integrated facilities: (1) Cayo Santiago, a unique free-ranging island colony of Indian-origin rhesus monkeys (Macaca mulatta);(2) the Sabana Seca Field Station, the CPRC's headquarters located 10 miles outside of San Juan, that houses rhesus monkeys derived from the Cayo Santiago colony in various outdoor configurations for biomedical and behavioral studies that are not feasible on free-ranging animals;(3) the Laboratory of Virology and Genetics (LVG), located on the Medical Sciences Campus (MSC), in San Juan;and (4) the Laboratory of Primate Morphology and Genetics (LPMG), which is also located on the MSC, and houses the CPRC Skeletal Collections, unique assemblages of nonhuman primate skeletons for genetic, developmental, pathological and anatomical research. As described in this proposal, CPRC is organized into four complementary and integrated divisions: Primate Resources, Virology and Genetics, Behavior and Neurosciences, and Primate Morphology &Genetics. Funds are requested in this application only to maintain CPRC basic infrastructure of Primate Resources, which are used to support numerous research projects across the United States. This core grant will also allow CPRC to seek additional support to launch collaborative research projects with mainland and international investigators. With continued NIH support, the CPRC will remain a significant national research resource and will be able to provide healthy Indian-origin rhesus monkeys of defined genetic and virological background to NIH-sponsored research programs.
(provided by applicant): The CPRC continues to be a platform that supports numerous PHS-sponsored research projects throughout USA. The Center provides Indian-origin rhesus monkeys which serve as models for the development of effective treatments against human diseases. With the needed NCRR support to this grant, the CPRC will continue to be one of the largest nationwide providers of SPF and of conventional rhesus monkeys required for AIDS and for other biomedical research projects and a valuable research resource needed for behavioral and biomedical studies.
|Rosati, Alexandra G; Santos, Laurie R (2017) Tolerant Barbary macaques maintain juvenile levels of social attention in old age, but despotic rhesus macaques do not. Anim Behav 130:199-207|
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|Ebersole, J L; Kirakodu, S; Novak, M J et al. (2016) Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa. Mol Oral Microbiol 31:18-32|
|Gonzalez, O A; Nagarajan, R; Novak, M J et al. (2016) Immune system transcriptome in gingival tissues of young nonhuman primates. J Periodontal Res 51:152-63|
|Wang, Qian; Kessler, Matthew J; Kensler, Terry B et al. (2016) The mandibles of castrated male rhesus macaques (Macaca mulatta): The effects of orchidectomy on bone and teeth. Am J Phys Anthropol 159:31-51|
|Ebersole, Jeffrey L; Kirakodu, Sreenatha S; Novak, M John et al. (2016) Transcriptome Analysis of B Cell Immune Functions in Periodontitis: Mucosal Tissue Responses to the Oral Microbiome in Aging. Front Immunol 7:272|
|Zhdanova, Irina V; Rogers, Jeffrey; González-Martínez, Janis et al. (2016) The ticking clock of Cayo Santiago macaques and its implications for understanding human circadian rhythm disorders. Am J Primatol 78:117-26|
|Kessler, Matthew J; Wang, Qian; Cerroni, Antonietta M et al. (2016) Long-term effects of castration on the skeleton of male rhesus monkeys (Macaca mulatta). Am J Primatol 78:152-66|
|Rosati, Alexandra G; Santos, Laurie R (2016) Spontaneous Metacognition in Rhesus Monkeys. Psychol Sci 27:1181-91|
|Wang, Qian; Turnquist, Jean E; Kessler, Matthew J (2016) Free-ranging Cayo Santiago rhesus monkeys (Macaca mulatta): III. Dental eruption patterns and dental pathology. Am J Primatol 78:127-42|
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