Rats are the optimal model for many research studies aimed at gaining a better understanding of human health and developing more effective cures and therapies for human diseases. The Rat Resource and Research Center (RRRC) was established in 2001 to provide the biomedical community with the requisite infrastructure for archiving and distributing rat models. In the four years since the RRRC started, the RRRC has exceeded the 5-year goals by importing more strains (69) than we were funded to import (50) and by establishing not only a national repository and distribution center, but an international network of rat repositories that links biomedical researchers with rat models available in nearly every part of the world. The RRC has also accepted another 176 rat lines from the NIH rat repositories. Additionally, research performed at the RRRC significantly advanced cryobiology, infectious disease detection and assisted reproductive technologies (ART) for the rat. The RRRC has become an essential resource to in the worldwide community of animal-based research.
The Specific Aims of this proposal build on the strengths of the established repository and distribution functions of the RRRC and focus research efforts on developing technologies to overcome current impediments to rat research. To accomplish these goals, the following Specific Aims are proposed: 1. A major goal of this proposal is to expand and improve the repository and distribution functions of the RRRC by (a) actively recruiting rat models into the Center, (b) increasing the efficiency for archiving and reanimating rat lines, (c) continuing to foster the international network of rat repositories, (d) continuing to distribute high quality rats, (e) making rat tissues and reagents available, and (f) aggressively disseminating information about the RRRC and the services it can provide to investigators. Together these efforts will result in a resource that meets the needs of the global biomedical research community. 2. To conduct research aimed at providing new services and technologies that will benefit researchers throughout the scientific community who use rats. Research projects will include developing : (a) purified recombinant rat luteinizing hormone (rl_H) and rat follicle stimulating hormone (rFSH) to develop improved protocols for superovulation of rats;and (b) innovative biosensor technologies to enhance detection of infectious agents in laboratory rats.
|Kim, Suhee; Hooper, Sarah; Agca, Cansu et al. (2016) Post-thaw ATP supplementation enhances cryoprotective effect of iodixanol in rat spermatozoa. Reprod Biol Endocrinol 14:5|
|Agca, Cansu; Agca, Yuksel (2014) Molecular and ultrastuctural changes of rat pre-implantation embryos during two-cell developmental arrest. J Assist Reprod Genet 31:767-80|
|Kim, Suhee; Agca, Cansu; Agca, Yuksel (2013) Effects of various physical stress factors on mitochondrial function and reactive oxygen species in rat spermatozoa. Reprod Fertil Dev 25:1051-64|
|Kim, Suhee; Agca, Cansu; Agca, Yuksel (2012) Changes in rat spermatozoa function after cooling, cryopreservation and centrifugation processes. Cryobiology 65:215-23|
|Men, Hongsheng; Bauer, Beth A; Bryda, Elizabeth C (2012) Germline transmission of a novel rat embryonic stem cell line derived from transgenic rats. Stem Cells Dev 21:2606-12|
|Agca, Yuksel (2012) Genome resource banking of biomedically important laboratory animals. Theriogenology 78:1653-65|
|Han, Xu; Liu, Yang; Critser, John K (2010) Determination of the quaternary phase diagram of the water-ethylene glycol-sucrose-NaCl system and a comparison between two theoretical methods for synthetic phase diagrams. Cryobiology 61:52-7|
|Jiao, A J; Ma, H B; Critser, J K (2009) Experimental investigation of cryogenic oscillating heat pipes. Int J Heat Mass Transf 52:3504-3509|
|Jiao, Anjun; Zhang, Yuwen; Ma, Hongbin et al. (2009) Effects of Lewis number on coupled heat and mass transfer in a circular tube subjected to external convective heating. J Heat Transfer 45:591-598|
|Han, Xu; Ma, Hongbin; Jiao, Anjun et al. (2008) Investigations on the heat transport capability of a cryogenic oscillating heat pipe and its application in achieving ultra-fast cooling rates for cell vitrification cryopreservation. Cryobiology 56:195-203|
Showing the most recent 10 out of 17 publications