This proposal requests continued support for the MIT/Harvard Center for Magnetic Resonance (CMR) located at the Francis Bitter Magnet Laboratory, MIT (EB002026). During the coming five-year period we plan significant upgrades of existing equipment, acquisition of new instrumentation, and research initiatives in several new areas. During the proposed five year grant period, we plan to initiate or complete construction or acquisition of the following new pieces of equipment, which will be integrated into the facility. These instruments will include the following: (1) a 460 GHz/700 MHz dynamic nuclear polarization (DNP)/NMR spectrometer;(2) an 800 MHz/89 mm NMR primarily for solids and conversion of the 750/62 to a solution spectrometer;(3) a 140 GHz gyroamplifier for time domain DNP and EPR experiments;(4) a 600 MHz/125 mm spectrometer for temperature jump DNP experiments. This will entail construction of a 395 GHz gyrotron oscillator for the DNP experiments;(5) a helium recirculation system for MAS experiments in the 20-30 K regime;(6) a tunable 330 GHz gyrotron oscillator that will be interfaced to an existing 500/104 spectrometer;(7) a commercial 9 GHz time domain EPR for distance measurements. In addition we will continue the strong core, collaborative and user research programs. Scientific topics include membrane proteins, signaling, metabolomics, and amyloid proteins associated with disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB002026-38
Application #
8464569
Study Section
Special Emphasis Panel (ZRG1-BCMB-N (40))
Program Officer
Sastre, Antonio
Project Start
1976-05-01
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
38
Fiscal Year
2013
Total Cost
$1,026,774
Indirect Cost
$388,888
Name
Massachusetts Institute of Technology
Department
Type
Organized Research Units
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Schaub, S C; Shapiro, M A; Temkin, R J (2016) Simple Expressions for the Design of Linear Tapers in Overmoded Corrugated Waveguides. J Infrared Millim Terahertz Waves 37:100-110
Sun, Zhen-Yu J; Bhanu, Meera K; Allan, Martin G et al. (2016) Solution Structure of the Cuz1 AN1 Zinc Finger Domain: An Exposed LDFLP Motif Defines a Subfamily of AN1 Proteins. PLoS One 11:e0163660
Takeuchi, Koh; Arthanari, Haribabu; Imai, Misaki et al. (2016) Nitrogen-detected TROSY yields comparable sensitivity to proton-detected TROSY for non-deuterated, large proteins under physiological salt conditions. J Biomol NMR 64:143-51
Zhukhovitskiy, Aleksandr V; Zhong, Mingjiang; Keeler, Eric G et al. (2016) Highly branched and loop-rich gels via formation of metal-organic cages linked by polymers. Nat Chem 8:33-41
Dev, Jyoti; Park, Donghyun; Fu, Qingshan et al. (2016) Structural basis for membrane anchoring of HIV-1 envelope spike. Science 353:172-5
Viegas, Aldino; Viennet, Thibault; Yu, Tsyr-Yan et al. (2016) UTOPIA NMR: activating unexploited magnetization using interleaved low-gamma detection. J Biomol NMR 64:9-15
Fu, Qingshan; Fu, Tian-Min; Cruz, Anthony C et al. (2016) Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor. Mol Cell 61:602-13
Salvi, Nicola; Papadopoulos, Evangelos; Blackledge, Martin et al. (2016) The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex. Angew Chem Int Ed Engl 55:7176-9
Nishikawa, Joy L; Boeszoermenyi, Andras; Vale-Silva, Luis A et al. (2016) Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. Nature 530:485-9
Oxenoid, Kirill; Dong, Ying; Cao, Chan et al. (2016) Architecture of the mitochondrial calcium uniporter. Nature 533:269-73

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