The objectives of the Center for Gamma-Ray Imaging are to develop advanced gamma-ray detectors and imaging systems, to push the limits of spatial and temporal resolution in SPECT and PET, and to make state-of-the-art technology available to our collaborators and to the biomedical research community. Much of the emphasis is on basic research with animal models, but there are many possibilities for translating the technology and the results of the collaborative research into clinical practice. We strive to integrate the components of the P41 mechanism (core technology development, collaborative research, service, dissemination and training) into a comprehensive program that addresses all aspects of gamma-ray imaging, including the radiopharmaceutical, image formation and detection, data acquisition and processing and the final biomedical application. The core technology projects include development of new gamma-ray and charged-particle detectors with high sensitivity and high spatial and temporal resolution; design and construction of new imaging systems incorporating sophisticated list-mode data-acquisition electronics; rigorous task-based evaluation and optimization of imaging systems and algorithms; design and analysis of adaptive and multimodality systems; and development of image-acquisition and image-analysis methods for molecular imaging. Collaborative research includes projects in cancer diagnosis and therapy, neurological and cardiovascular disease, stem cells, image science in nuclear medicine, and imaging biomarkers. Dissemination includes supplying imaging hardware and software to our collaborators, as well as workshops and a web site for traditional dissemination of information. Training includes both formal short courses and hands-on training for our collaborators in Tucson. Service includes performing routine animal studies, testing and calibrating detectors and detector materials, and providing advice on image quality.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB002035-20
Application #
9502281
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Atanasijevic, Tatjana
Project Start
1999-08-01
Project End
2019-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
20
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Arizona
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Ghanbari, Nasrin; Clarkson, Eric; Kupinski, Matthew et al. (2017) Optimization of an Adaptive SPECT System with the Scanning Linear Estimator. IEEE Trans Radiat Plasma Med Sci 1:435-443
Ding, Yijun; Caucci, Luca; Barrett, Harrison H (2017) Null functions in three-dimensional imaging of alpha and beta particles. Sci Rep 7:15807
Dickinson, Sally E; Janda, Jaroslav; Criswell, Jane et al. (2016) Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin. Cancer Prev Res (Phila) 9:215-24
Barrett, Harrison H; Alberts, David S; Woolfenden, James M et al. (2016) Therapy operating characteristic curves: tools for precision chemotherapy. J Med Imaging (Bellingham) 3:023502
Liu, Zhonglin; Gray, Brian D; Barber, Christy et al. (2016) Characterization of TCP-1 probes for molecular imaging of colon cancer. J Control Release 239:223-30
Clarkson, Eric; Barrett, Harrison H (2016) Characteristic functionals in imaging and image-quality assessment: tutorial. J Opt Soc Am A Opt Image Sci Vis 33:1464-75
Clarkson, Eric; Cushing, Johnathan B (2016) Shannon information for joint estimation/detection tasks and complex imaging systems. J Opt Soc Am A Opt Image Sci Vis 33:286-92
Liu, Zhonglin; Larsen, Brandon T; Lerman, Lilach O et al. (2016) Detection of atherosclerotic plaques in ApoE-deficient mice using (99m)Tc-duramycin. Nucl Med Biol 43:496-505
Bora, Vaibhav; Barrett, Harrison H; Fastje, David et al. (2016) Estimation of Fano factor in inorganic scintillators. Nucl Instrum Methods Phys Res A 805:72-86
Jha, Abhinav K; Barrett, Harrison H; Frey, Eric C et al. (2015) Singular value decomposition for photon-processing nuclear imaging systems and applications for reconstruction and computing null functions. Phys Med Biol 60:7359-85

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