This is the revision of the last renewal of a technology resource grant (P41) entitled """"""""A Resource on Medical Ultrasonic Transducer Technology"""""""". It was funded at Penn State University in 1997 to pursue innovative research in high frequency (HF) ultrasonic transducers and arrays as well as to serve the medical ultrasound community who has a need for such transducers and arrays. In 2002 the Resource was moved to USC and renewed in 2005. In the past 5 years, significant progress has been made in transducer materials, HF single element transducers and arrays, and imaging electronics, resulting in 101 refereed publications and 10 patents or patent disclosures. In addition, a new initiative on studying the feasibility of ultrasound microbeams defined as ultrasound beams at frequencies higher than 200 MHz was launched. Novel piezoelectric thin/thick films have been developed allowing ultrahigh frequency (UHF) transducers (200 MHz -1 GHz) to be designed and built. HF linear arrays at 30 MHz have been improved to consist of now 256 elements and a curved linear array at 20 MHz for imaging posterior side of the eye has been developed. Prototype real-time analog and digital HF imaging platforms are fully functional. Exploratory experiments on ultrasound microbeam for trapping cells, cell sorting, cellular mechanotransduction, and acoustic radiation force imaging of microstructures were carried out, demonstrating that exciting opportunities exist for ultrasound to play a more significant role in the promising field of cellulr bioengineering. There have been 17 collaborative projects and 8 service projects. In next grant period, there will be four internal core projects: (I) hovel transducer materials and UHF transducers (II) HF arrays and imaging platforms, (III) ultrasound microbeam, and (IV) novel piezoelectric materials and HF material characterization along with 15 collaborative projects and 4 service projects. The major thrusts of the core research will be (1) to develop UHF single element transducers for microbeam applications, (2) to develop a 35 MHz phased array and imaging platform for cardiac imaging in small animals, (3) to develop linear arrays at 50 MHz and higher and curved linear arrays in the 15 - 20 MHz range, and (4) to exploit cellular applications of ultrasound microbeams.

Public Health Relevance

This project is focused at developing ultrasonic devices at a frequency much higher than that commonly used in clinical scanning. They can be used to image the eye, skin and small animals. They can also be used to interrogate and manipulate cells if the frequency is increased to beyond 200 MHz.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Biotechnology Resource Grants (P41)
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Special Emphasis Panel (ZEB1-OSR-C (M2))
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Lopez, Hector
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University of Southern California
Biomedical Engineering
Schools of Engineering
Los Angeles
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Yoon, Sangpil; Kim, Min Gon; Chiu, Chi Tat et al. (2016) Direct and sustained intracellular delivery of exogenous molecules using acoustic-transfection with high frequency ultrasound. Sci Rep 6:20477
Fei, Chunlong; Li, Ying; Zhu, Benpeng et al. (2016) Contactless microparticle control via ultrahigh frequency needle type single beam acoustic tweezers. Appl Phys Lett 109:173509
Hwang, Jae Youn; Kim, Jihun; Park, Jin Man et al. (2016) Cell Deformation by Single-beam Acoustic Trapping: A Promising Tool for Measurements of Cell Mechanics. Sci Rep 6:27238
Ma, Jianguo; Luo, Yuan; Sevag Packard, René R et al. (2016) Ultrasonic Transducer-Guided Electrochemical Impedance Spectroscopy to Assess Lipid-Laden Plaques. Sens Actuators B Chem 235:154-161
Cummins, Thomas; Eliahoo, Payam; Kirk Shung, K (2016) High-Frequency Ultrasound Array Designed for Ultrasound-Guided Breast Biopsy. IEEE Trans Ultrason Ferroelectr Freq Control 63:817-27
Tang, Liguo; Tian, Hua; Zhang, Yu et al. (2016) Temperature dependence of dielectric, elastic, and piezoelectric constants of [001]c poled Mn-doped 0.24Pb(In1/2Nb1/2)O3-0.46Pb(Mg1/3Nb2/3)O3-0.30PbTiO3 single crystal. Appl Phys Lett 108:082901
Chang, Ya-Ju; Huang, Hui-Chun; Hsueh, Yuan-Yu et al. (2016) Role of Excessive Autophagy Induced by Mechanical Overload in Vein Graft Neointima Formation: Prediction and Prevention. Sci Rep 6:22147
Tang, Liguo; Cao, Wenwu (2016) Characterization of Full Set Material Constants and Their Temperature Dependence for Piezoelectric Materials Using Resonant Ultrasound Spectroscopy. J Vis Exp :
Lin, Shih-Ping; Lin, Yi-Hsun; Fan, Shih-Chen et al. (2016) Cross-Sectional Nakagami Images in Passive Stretches Reveal Damage of Injured Muscles. Biomed Res Int 2016:6893712
Zheng, Limei; Jing, Yujia; Lu, Xiaoyan et al. (2016) Temperature and electric-field induced phase transitions, and full tensor properties of [011] C -poled domain-engineered tetragonal 0.63Pb(Mg1/3Nb2/3)-0.37PbTiO3 single crystals. Phys Rev B 93:

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