Microfabrication techniques or microelectromechanical systems (MEMS) that have revolutionized the electronics industry are now poised to revolutionize the pharmaceutical &biotechnology industries, &basic biomedical sciences. The two leading applications of microfabrication in biology include """"""""genes-on-a-chip"""""""" to monitor the expression level of potentially all genes in humans &organisms simultaneously, &""""""""lab-on-a-chip"""""""" type devices to perform high-throughput biochemistry in very small volumes. Equally exciting is recent advances in the understanding of cellular behavior in microenvironments have started to pave the way towards living micro-devices. The emerging integration of living systems &MEMS are expected to become key technologies in the 21st century of medicine with a broad range of applications varying from diagnostic, therapeutics, cell-based high-throughput drug screening tools, &basic &applied cell biology tools. The mission for the proposed NIH BioMEMS Resource Center is to bridge the gap between MEMS engineering &biomedical community to provide new technologies at the interface of MEMS &living biological systems to biomedical investigators &clinicians. In order to make the tools of BioMEMS available to the biomedical community, we focused our efforts on 2 core technological research &development projects. In Core Project 1, we will use inertial microfluidic technology for high-throughput &precise microscale control of cell &particle motion for sorting &analysis of disease specific """"""""rare"""""""" cells in blood. In Core Project 2, we will develop broad utility """"""""living cell array"""""""" platforms to study the dynamics of cellular &tissue response to a multitude of stimuli. Also, there are 23 collaborative projects that both utilize &help advance the core technologies. The BMRC also provides services to NIH investigators to use the tools of microsystems technology in biology &medicine. The Core, Collaborative, &Service activities are complemented with a rich portfolio of training &dissemination activities. Our collaborators &service users are extremely well-funded NIH investigators. The training activities include ad-hoc training, laboratory courses, &workshops. The dissemination activities are very broad encompassing publications, presentations, web presence, symposia &meetings, visiting faculty program, &technology transfer. We have also been very successful in disseminating our technologies through licensing &spin-off commercialization and the use of MEMS foundries for manufacturing of microchips. BMRC has been very successful in developing cutting-edge, enabling technologies at the Interface of MEMS &biology, &disseminating these technologies to the biomedical community via collaborations, service activities, &organized training &dissemination programs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB002503-08
Application #
8115147
Study Section
Special Emphasis Panel (ZRG1-BST-R (40))
Program Officer
Hunziker, Rosemarie
Project Start
2004-04-01
Project End
2014-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
8
Fiscal Year
2011
Total Cost
$1,201,347
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Park, Myoung-Hwan; Reátegui, Eduardo; Li, Wei et al. (2017) Enhanced Isolation and Release of Circulating Tumor Cells Using Nanoparticle Binding and Ligand Exchange in a Microfluidic Chip. J Am Chem Soc 139:2741-2749
Dang, Irène; Linkner, Joern; Yan, Jun et al. (2017) The Arp2/3 inhibitory protein Arpin is dispensable for chemotaxis. Biol Cell 109:162-166
Fachin, Fabio; Spuhler, Philipp; Martel-Foley, Joseph M et al. (2017) Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells. Sci Rep 7:10936
Jalali, Fatemeh; Ellett, Felix; Irimia, Daniel (2017) Rapid antibiotic sensitivity testing in microwell arrays. Technology (Singap World Sci) 5:107-114
Chandrasekaran, Arvind; Ellett, Felix; Jorgensen, Julianne et al. (2017) Temporal gradients limit the accumulation of neutrophils towards sources of chemoattractant. Microsyst Nanoeng 3:
Huang, Haishui; Yu, Yin; Hu, Yong et al. (2017) Generation and manipulation of hydrogel microcapsules by droplet-based microfluidics for mammalian cell culture. Lab Chip 17:1913-1932
Gokaltun, Aslihan; Yarmush, Martin L; Asatekin, Ayse et al. (2017) Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology. Technology (Singap World Sci) 5:1-12
Jiang, Xiaocheng; Wong, Keith H K; Khankhel, Aimal H et al. (2017) Microfluidic isolation of platelet-covered circulating tumor cells. Lab Chip 17:3498-3503
Frydman, Galit H; Le, Anna; Ellett, Felix et al. (2017) Technical Advance: Changes in neutrophil migration patterns upon contact with platelets in a microfluidic assay. J Leukoc Biol 101:797-806
Zhou, Renjie; Jin, Di; Hosseini, Poorya et al. (2017) Modeling the depth-sectioning effect in reflection-mode dynamic speckle-field interferometric microscopy. Opt Express 25:130-143

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