Microfabrication techniques or microelectromechanical systems (MEMS) that have revolutionized the electronics industry are now poised to revolutionize the pharmaceutical &biotechnology industries, &basic biomedical sciences. The two leading applications of microfabrication in biology include "genes-on-a-chip" to monitor the expression level of potentially all genes in humans &organisms simultaneously, &"lab-on-a-chip" type devices to perform high-throughput biochemistry in very small volumes. Equally exciting is recent advances in the understanding of cellular behavior in microenvironments have started to pave the way towards living micro-devices. The emerging integration of living systems &MEMS are expected to become key technologies in the 21st century of medicine with a broad range of applications varying from diagnostic, therapeutics, cell-based high-throughput drug screening tools, &basic &applied cell biology tools. The mission for the proposed NIH BioMEMS Resource Center is to bridge the gap between MEMS engineering &biomedical community to provide new technologies at the interface of MEMS &living biological systems to biomedical investigators &clinicians. In order to make the tools of BioMEMS available to the biomedical community, we focused our efforts on 2 core technological research &development projects. In Core Project 1, we will use inertial microfluidic technology for high-throughput &precise microscale control of cell &particle motion for sorting &analysis of disease specific "rare" cells in blood. In Core Project 2, we will develop broad utility "living cell array" platforms to study the dynamics of cellular &tissue response to a multitude of stimuli. Also, there are 23 collaborative projects that both utilize &help advance the core technologies. The BMRC also provides services to NIH investigators to use the tools of microsystems technology in biology &medicine. The Core, Collaborative, &Service activities are complemented with a rich portfolio of training &dissemination activities. Our collaborators &service users are extremely well-funded NIH investigators. The training activities include ad-hoc training, laboratory courses, &workshops. The dissemination activities are very broad encompassing publications, presentations, web presence, symposia &meetings, visiting faculty program, &technology transfer. We have also been very successful in disseminating our technologies through licensing &spin-off commercialization and the use of MEMS foundries for manufacturing of microchips. BMRC has been very successful in developing cutting-edge, enabling technologies at the Interface of MEMS &biology, &disseminating these technologies to the biomedical community via collaborations, service activities, &organized training &dissemination programs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB002503-10
Application #
8517466
Study Section
Special Emphasis Panel (ZRG1-BST-R (40))
Program Officer
Hunziker, Rosemarie
Project Start
2004-04-01
Project End
2014-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
10
Fiscal Year
2013
Total Cost
$1,092,941
Indirect Cost
$474,494
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Aranyosi, Alexander J; Wong, Elisabeth A; Irimia, Daniel (2015) A neutrophil treadmill to decouple spatial and temporal signals during chemotaxis. Lab Chip 15:549-56
Bohr, Stefan; Patel, Suraj J; Vasko, Radovan et al. (2015) Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells. J Mol Med (Berl) 93:199-210
Luo, Xi; Mitra, Devarati; Sullivan, Ryan J et al. (2014) Isolation and molecular characterization of circulating melanoma cells. Cell Rep 7:645-53
Sullivan, James P; Nahed, Brian V; Madden, Marissa W et al. (2014) Brain tumor cells in circulation are enriched for mesenchymal gene expression. Cancer Discov 4:1299-309
Aceto, Nicola; Bardia, Aditya; Miyamoto, David T et al. (2014) Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. Cell 158:1110-22
Boneschansker, Leo; Yan, Jun; Wong, Elisabeth et al. (2014) Microfluidic platform for the quantitative analysis of leukocyte migration signatures. Nat Commun 5:4787
Yan, Jun; Irimia, Daniel (2014) Stochastic variations of migration speed between cells in clonal populations. Technology (Singap World Sci) 2:185-188
Yu, Min; Bardia, Aditya; Aceto, Nicola et al. (2014) Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science 345:216-20
Wong, Ian Y; Javaid, Sarah; Wong, Elisabeth A et al. (2014) Collective and individual migration following the epithelial-mesenchymal transition. Nat Mater 13:1063-71
Cho, Hansang; Hamza, Bashar; Wong, Elisabeth A et al. (2014) On-demand, competing gradient arrays for neutrophil chemotaxis. Lab Chip 14:972-8

Showing the most recent 10 out of 115 publications