The P41 Tissue Engineering Resource Center (TERC) has established innovative biomaterials, bioreactors, and tissue engineering models since its inception in August 2004. The core themes for TERC continue to evolve along with the scientific and technological progress. Initially the focus was on functional tissue engineering achieved through the integration of the key elements in the field via a systems approach - cells, scaffolds and bioreactors. This renewal continues this path, with an expanded impact for the Center themes in areas of clinical relevance, disease models, and research tools applicable to biological inquiry. In the renewal plans, we maintain a focus in two critical areas: (a) skeletal systems and (b) cardiovascular systems, while progressing toward new impact for the underlying fundamentals and translational strategies. The common aspects for both areas (skeletal tissues, cardiovascular systems) include: cell sources, genetic tools, imaging (molecular, cellular, tissue levels), biomechanics (from cells to tissues), modeling (computational biology, transport, electrical and mechanical signal transduction) and the use of animal models, with strong focus on advancing biological research and translation into medical applications. The Center will continue to be led by two long-time collaborators, David Kaplan at Tufts University and Gordana Vunjak-Novakovic at Columbia University, who also head the two cores in the Center (biomaterials, bioreactors). A large group of faculty and collaborators will contribute the activities in the Center, and a stellar Scientific Advisory Board will continue to provide critical guidance to the Center.

Public Health Relevance

The need for new ways to design, study and use human tissues continues to grow. Thus, the focus and importance of Center programs continues to expand, with impact in understanding disease, repairing clinical defects for tissue and organ needs, and to screen therapeutic treatments

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Biotechnology Resource Grants (P41)
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Special Emphasis Panel (ZRG1-BST-Z (40))
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Hunziker, Rosemarie
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Tufts University
Engineering (All Types)
Schools of Engineering
United States
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Parsa, Hesam; Ronaldson, Kacey; Vunjak-Novakovic, Gordana (2016) Bioengineering methods for myocardial regeneration. Adv Drug Deliv Rev 96:195-202
Yigit, Sezin; Dinjaski, Nina; Kaplan, David L (2016) Fibrous proteins: At the crossroads of genetic engineering and biotechnological applications. Biotechnol Bioeng 113:913-29
Cigan, Alexander D; Nims, Robert J; Vunjak-Novakovic, Gordana et al. (2016) Optimizing nutrient channel spacing and revisiting TGF-beta in large engineered cartilage constructs. J Biomech 49:2089-94
Eng, George; Lee, Benjamin W; Protas, Lev et al. (2016) Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes. Nat Commun 7:10312
Han, Hongyan; Ning, Hongyan; Liu, Shanshan et al. (2016) Silk Biomaterials with Vascularization Capacity. Adv Funct Mater 26:421-436
Brown, Joseph E; Moreau, Jodie E; Berman, Alison M et al. (2016) Shape Memory Silk Protein Sponges for Minimally Invasive Tissue Regeneration. Adv Healthc Mater :
Ma, Stephen P; Vunjak-Novakovic, Gordana (2016) Tissue-Engineering for the Study of Cardiac Biomechanics. J Biomech Eng 138:021010
Liu, Zen; Vunjak-Novakovic, Gordana (2016) Modeling tumor microenvironments using custom-designed biomaterial scaffolds. Curr Opin Chem Eng 11:94-105
Belanger, Kayla; Dinis, Tony M; Taourirt, Sami et al. (2016) Recent Strategies in Tissue Engineering for Guided Peripheral Nerve Regeneration. Macromol Biosci 16:472-81
Marturano-Kruik, Alessandro; Villasante, Aranzazu; Vunjak-Novakovic, Gordana (2016) Bioengineered Models of Solid Human Tumors for Cancer Research. Methods Mol Biol 1502:203-11

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