The Tissue Engineering Resource Center (TERC) continues to be grounded in strong foundational work on advanced biomaterials and bioreactor systems, while Technology &Research Development Projects (T&RD) have evolved along with the significant scientific and technological progress made by the Center and its many collaborators and associates.At its inception, the Center focus of the TERC research was on functional tissue engineering and regenerative medicine, through the integration of the key elements - cells, scaffolds and bioreactos, via a systems approach. In 2008, the Center was renewed for an additional five years of funding support With that renewal, the Center continue to build upon its core research to renew and refine the biomaterials, bioreactors and imaging tools while expanding its research portfolio to include more complex tissues, and more sophisticated data acquisition and control strategies. Great strides have been made toward this goal during the past eight years. Tissue engineering and regenerative medicie continue to rely on advances at the fundamental level, while supporting clinical and industrial effrts with significant impact on human health. As we look to the next five years, TERC is uniquely positined to help advance the field precisely because it maintains a core research program in the fundamental of tissue engineering (stem cell biology, tissue biomechanics, bioreactor design, biomaterials development, integration with imaging), while pushing the field forward with preclinical studies, translation activities, development of platform technologies, and disease modeling. Our research ha spawned collaborative projects, service projects, and many other opportunities that feed into our fundamental research. As we continue to develop more complex and customized biomaterial and bioreactor systems, we initiate collaborations in new tissue types and disease states. The lessons learned are expected to further strengthen the foundational research with new demands on our systems. This research feedback loop has resulted in significant advances and new directions for th Center while maintaining solid foundational work

Public Health Relevance

Tissue Engineering continues to represent a significant potential for biomedical advances. The TERC continues to support the Tissue Engineering Field in the goal of developing functional tissue grafts to improve the clinical outcomes for tissu grafting, disease modeling, and a better fundamental understanding of the engineering of biological systems.

Agency
National Institute of Health (NIH)
Type
Biotechnology Resource Grants (P41)
Project #
2P41EB002520-11
Application #
8476666
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Hunziker, Rosemarie
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Tufts University
Department
Engineering (All Types)
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
City
Medford
State
MA
Country
United States
Zip Code
02155
Parsa, Hesam; Ronaldson, Kacey; Vunjak-Novakovic, Gordana (2016) Bioengineering methods for myocardial regeneration. Adv Drug Deliv Rev 96:195-202
Yigit, Sezin; Dinjaski, Nina; Kaplan, David L (2016) Fibrous proteins: At the crossroads of genetic engineering and biotechnological applications. Biotechnol Bioeng 113:913-29
Cigan, Alexander D; Nims, Robert J; Vunjak-Novakovic, Gordana et al. (2016) Optimizing nutrient channel spacing and revisiting TGF-beta in large engineered cartilage constructs. J Biomech 49:2089-94
Eng, George; Lee, Benjamin W; Protas, Lev et al. (2016) Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes. Nat Commun 7:10312
Han, Hongyan; Ning, Hongyan; Liu, Shanshan et al. (2016) Silk Biomaterials with Vascularization Capacity. Adv Funct Mater 26:421-436
Brown, Joseph E; Moreau, Jodie E; Berman, Alison M et al. (2016) Shape Memory Silk Protein Sponges for Minimally Invasive Tissue Regeneration. Adv Healthc Mater :
Ma, Stephen P; Vunjak-Novakovic, Gordana (2016) Tissue-Engineering for the Study of Cardiac Biomechanics. J Biomech Eng 138:021010
Liu, Zen; Vunjak-Novakovic, Gordana (2016) Modeling tumor microenvironments using custom-designed biomaterial scaffolds. Curr Opin Chem Eng 11:94-105
Belanger, Kayla; Dinis, Tony M; Taourirt, Sami et al. (2016) Recent Strategies in Tissue Engineering for Guided Peripheral Nerve Regeneration. Macromol Biosci 16:472-81
Marturano-Kruik, Alessandro; Villasante, Aranzazu; Vunjak-Novakovic, Gordana (2016) Bioengineered Models of Solid Human Tumors for Cancer Research. Methods Mol Biol 1502:203-11

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