The Massachusetts Institute of Technology (MIT) Laser Biomedical Research Center (LBRC) is a NIH NIBIB research resource. The LBRC is also a part of the G.R. Harrison Spectroscopy Laboratory (SpecLab) administrated by the Department of Chemistry. The LBRC will enter its next funding cycle with seven senior investigators with approximately 10-15 junior staff members managing approximately 40 collaborative and service projects. Comparatively speaking, the LBRC is not a large facility; however, given that the center lies at the intersection seven senior investigator laboratories and interactions with a web of national and international collaborations with over 100 associated personnel, the LBRC is a fairly complex enterprise that needs an efficient management plan with a clear chain of responsibilities to properly function. The leadership team of the LBRC further believes that the majority of the financial resource of the LBRC should be devoted to research, collaborations, and training/dissemination. Therefore, the center's guiding management philosophy is best encapsulated by Albert Einstein's saying: ?Make everything as simple as possible, but not simpler.? We have been and will continue to keep a very lean budget for administration. We are able to function well with minimal administrative expenditure for two reasons: First, as a part of MIT Department of Chemistry and the School of Science, we can leverage the very well-run, larger administrative infrastructure for many LBRC operations. Second, and probably most importantly, we have a highly energetic and collaborative group of senior investigators. While all of us have research and teaching roles beyond our involvement in the LBRC, having an enthusiastic group of senior investigators who are willing to take up administrative and management roles within their busy schedule is partly the reason for success of our center so far. Given our success in the last four years, we see no reason for radical changes. In summary, the LBRC administrative plan has five components: (1) LBRC organization: Describe relationship of LBRC within grantee institution and delineate administrative and operational responsibilities among senior investigators and key staff members. (2) LBRC External Advisory Committee (EAC): Review LBRC EAC structure and membership renewal plan. (3) LBRC operating procedures: Layout / review procedures for CP an SP management, equipment and facility usages, and facility user training. (4) Internal communication and networking plans: (a) Establish new TRD-wide and Center-wide regular meetings, (b) Establish a LBRC Retreat (5) Transition plan towards maintaining operations and service after ?sunset?.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
2P41EB015871-31
Application #
9358912
Study Section
Special Emphasis Panel (ZEB1)
Project Start
Project End
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
31
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02142
Jonas, Oliver; Kang, Jeon Woong; Singh, Surya P et al. (2018) In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy. Analyst 143:4836-4839
Bartelt, Alexander; Widenmaier, Scott B; Schlein, Christian et al. (2018) Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nat Med 24:292-303
Ahmad, Azeem; Dubey, Vishesh; Singh, Vijay Raj et al. (2018) Quantitative phase microscopy of red blood cells during planar trapping and propulsion. Lab Chip 18:3025-3036
Singh, Surya P; Mukherjee, Soumavo; Galindo, Luis H et al. (2018) Evaluation of accuracy dependence of Raman spectroscopic models on the ratio of calibration and validation points for non-invasive glucose sensing. Anal Bioanal Chem 410:6469-6475
Wadduwage, Dushan N; Kay, Jennifer; Singh, Vijay Raj et al. (2018) Automated fluorescence intensity and gradient analysis enables detection of rare fluorescent mutant cells deep within the tissue of RaDR mice. Sci Rep 8:12108
Zhang, Chi; Winnard Jr, Paul T; Dasari, Sidarth et al. (2018) Label-free Raman spectroscopy provides early determination and precise localization of breast cancer-colonized bone alterations. Chem Sci 9:743-753
Rizwan, Asif; Paidi, Santosh Kumar; Zheng, Chao et al. (2018) Mapping the genetic basis of breast microcalcifications and their role in metastasis. Sci Rep 8:11067
Xue, Yi; So, Peter T C (2018) Three-dimensional super-resolution high-throughput imaging by structured illumination STED microscopy. Opt Express 26:20920-20928
Pandey, Rishikesh; Singh, Surya P; Zhang, Chi et al. (2018) Label-free spectrochemical probe for determination of hemoglobin glycation in clinical blood samples. J Biophotonics 11:e201700397
Carr, Jessica A; Franke, Daniel; Caram, Justin R et al. (2018) Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green. Proc Natl Acad Sci U S A 115:4465-4470

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