The Laser Microbeam and Medical Program (LAMMP), is dedicated to the use of lasers and optics in Biology and Medicine. LAMMP is located within the Beckman Laser Institute and Medical Clinic, an interdisciplinary biomedical research, teaching, and clinical facility at the University of California, Irvine. LAMMP activities span from basic science and technology development to clinical translational research. This is accomplished by combining state of the art Biophotonics technologies with specialized resource facilities for cell and tissue engineering, histopathology, pre-clinical animal models, and clinica care. LAMMP programs include Biophotonics modeling and technology development, basic science studies, instrument prototyping, and device testing in humans and animal models. Because of our facilities, resources, and expertise, we are able to rapidly move new concepts and technologies from blackboard to bench-top to bedside. In this seventh renewal application of LAMMP, we continue to transform our center by advancing several new technologies and high-impact collaborations. We propose to consolidate our activities into 4 major areas of Technology Research and Development (TR&D): Virtual Photonics Technologies (VPT), Microscopy and Microbeam Technologies (MMT), Multimodality Endoscopic Technologies (MET), and Diffuse Optics Technologies (DOT).
Specific Aims are proposed for each TR&D core that will result in the development of several state-of-the-art technologies, instruments, and computational methods. Together, the four TR&D cores contain complementary, inter-dependent approaches for quantitatively characterizing, imaging, and perturbing structure and biochemical function in cells and tissues with scalable resolution and depth sensitivity ranging from micrometers to centimeters. Our broad goal is to advance these technologies through collaboration, service, training, and dissemination activities so they become widely-available, enabling methods for solving important problems in Biology and Medicine.
LAMMP basic science and technology discoveries are developed in a multidisciplinary environment and rapidly moved from blackboard to bench-top to bedside. New methods and devices are proposed that have direct relevance in detecting and treating cancer, vascular and neurologic diseases, and metabolic disorders, as well as providing new insights on fundamental biological processes, such as mechano-transduction, wound repair, angiogenesis, and cell death.
|Ghijsen, Michael; Choi, Bernard; Durkin, Anthony J et al. (2016) Real-time simultaneous single snapshot of optical properties and blood flow using coherent spatial frequency domain imaging (cSFDI). Biomed Opt Express 7:870-82|
|Kim, Seong M; Roy, Saurabh G; Chen, Bin et al. (2016) Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest 126:4088-4102|
|Manuel, Cyrus T; Tjoa, Tjoson; Nguyen, Tony et al. (2016) Optimal Electromechanical Reshaping of the Auricular Ear and Long-term Outcomes in an In Vivo Rabbit Model. JAMA Facial Plast Surg 18:277-84|
|Qi, Li; Zhu, Jiang; Hancock, Aneeka M et al. (2016) Fully distributed absolute blood flow velocity measurement for middle cerebral arteries using Doppler optical coherence tomography. Biomed Opt Express 7:601-15|
|Madsen, Steen J; Shih, En-Chung; Peng, Qian et al. (2016) Photothermal enhancement of chemotherapy mediated by gold-silica nanoshell-loaded macrophages: in vitro squamous cell carcinoma study. J Biomed Opt 21:18004|
|Ganesan, G; Warren, R V; Leproux, A et al. (2016) Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss. Int J Obes (Lond) 40:1292-300|
|Christie, Catherine; Molina, Stephanie; Gonzales, Jonathan et al. (2016) Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization. Biomed Opt Express 7:1240-50|
|Sumbria, Rachita K; Grigoryan, Mher Mahoney; Vasilevko, Vitaly et al. (2016) A murine model of inflammation-induced cerebral microbleeds. J Neuroinflammation 13:218|
|Regan, Caitlin; Choi, Bernard (2016) Laser speckle imaging based on photothermally driven convection. J Biomed Opt 21:26011|
|Hou, Jue; Wright, Heather J; Chan, Nicole et al. (2016) Correlating two-photon excited fluorescence imaging of breast cancer cellular redox state with seahorse flux analysis of normalized cellular oxygen consumption. J Biomed Opt 21:60503|
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