The Laser Microbeam and Medical Program (LAMMP), is dedicated to the use of lasers and optics in Biology and Medicine. LAMMP is located within the Beckman Laser Institute and Medical Clinic, an interdisciplinary biomedical research, teaching, and clinical facility at the University of California, Irvine. LAMMP activities span from basic science and technology development to clinical translational research. This is accomplished by combining state of the art Biophotonics technologies with specialized resource facilities for cell and tissue engineering, histopathology, pre-clinical animal models, and clinica care. LAMMP programs include Biophotonics modeling and technology development, basic science studies, instrument prototyping, and device testing in humans and animal models. Because of our facilities, resources, and expertise, we are able to rapidly move new concepts and technologies from blackboard to bench-top to bedside. In this seventh renewal application of LAMMP, we continue to transform our center by advancing several new technologies and high-impact collaborations. We propose to consolidate our activities into 4 major areas of Technology Research and Development (TR&D): Virtual Photonics Technologies (VPT), Microscopy and Microbeam Technologies (MMT), Multimodality Endoscopic Technologies (MET), and Diffuse Optics Technologies (DOT).
Specific Aims are proposed for each TR&D core that will result in the development of several state-of-the-art technologies, instruments, and computational methods. Together, the four TR&D cores contain complementary, inter-dependent approaches for quantitatively characterizing, imaging, and perturbing structure and biochemical function in cells and tissues with scalable resolution and depth sensitivity ranging from micrometers to centimeters. Our broad goal is to advance these technologies through collaboration, service, training, and dissemination activities so they become widely-available, enabling methods for solving important problems in Biology and Medicine.

Public Health Relevance

LAMMP basic science and technology discoveries are developed in a multidisciplinary environment and rapidly moved from blackboard to bench-top to bedside. New methods and devices are proposed that have direct relevance in detecting and treating cancer, vascular and neurologic diseases, and metabolic disorders, as well as providing new insights on fundamental biological processes, such as mechano-transduction, wound repair, angiogenesis, and cell death.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB015890-35
Application #
8652453
Study Section
Special Emphasis Panel (ZEB1-OSR-C (J1))
Program Officer
Conroy, Richard
Project Start
1997-04-21
Project End
2018-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
35
Fiscal Year
2014
Total Cost
$1,156,364
Indirect Cost
$374,528
Name
University of California Irvine
Department
Surgery
Type
Schools of Medicine
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Qu, Yueqiao; He, Youmin; Saidi, Arya et al. (2018) In Vivo Elasticity Mapping of Posterior Ocular Layers Using Acoustic Radiation Force Optical Coherence Elastography. Invest Ophthalmol Vis Sci 59:455-461
Cochran, Jeffrey M; Busch, David R; Leproux, Anaïs et al. (2018) Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment. J Biomed Opt 24:1-11
Ghijsen, Michael; Rice, Tyler B; Yang, Bruce et al. (2018) Wearable speckle plethysmography (SPG) for characterizing microvascular flow and resistance. Biomed Opt Express 9:3937-3952
Nair, Rohit Kumar; Christie, Catherine; Ju, David et al. (2018) Enhancing the effects of chemotherapy by combined macrophage-mediated photothermal therapy (PTT) and photochemical internalization (PCI). Lasers Med Sci 33:1747-1755
Moon, Sucbei; Qu, Yueqiao; Chen, Zhongping (2018) Characterization of spectral-domain OCT with autocorrelation interference response for axial resolution performance. Opt Express 26:7253-7269
Miao, Yusi; Jing, Joseph C; Desai, Vineet et al. (2018) Automated 3D segmentation of methyl isocyanate-exposed rat trachea using an ultra-thin, fully fiber optic optical coherence endoscopic probe. Sci Rep 8:8713
Lam, Jesse H; O'Sullivan, Thomas D; Park, Tim S et al. (2018) Non-invasive Dual-Channel Broadband Diffuse Optical Spectroscopy of Massive Hemorrhage and Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in Swine. Mil Med 183:150-156
White, Sean M; Valdebran, Manuel; Kelly, Kristen M et al. (2018) Simultaneous Blood Flow Measurement and Dermoscopy of Skin Lesions Using Dual-Mode Dermascope. Sci Rep 8:16941
Hirschberg, Henry; Berg, Kristian; Peng, Qian (2018) Photodynamic therapy mediated immune therapy of brain tumors. Neuroimmunol Neuroinflamm 5:
Ghijsen, Michael; Lentsch, Griffin R; Gioux, Sylvain et al. (2018) Quantitative real-time optical imaging of the tissue metabolic rate of oxygen consumption. J Biomed Opt 23:1-12

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