Renewal of the NCRR Center for Advanced Magnetic Resonance Technology is proposed. Magnetic resonance instrument manufacturers Introduce new technology in their products based on marketing and other factors that often preclude the timely availability of cutting edge research capabilities for investigators. To fill this gap, the Center will develop and make available innovative technologies in five core research areas of magnetic resonance imaging and spectroscopy (MRI/MRS): (1) image reconstruction, fast imaging and RF pulse design methods, (2) MR hardware, (3) body imaging methods, (4) neuroimaging methods, and (5) MR spectroscopy methods. In each of these areas, we will capitalize on the extensive experience in Stanford's Radiology and Electrical Engineering departments to improve and expand imaging technology for use in basic research and clinical care, and to provide cutting edge opportunities for biomedical research with MRI.. Over the past five years, the Center has been motivated by and has served a wide base of extramurally sponsored collaborators and service users from leading medical and research institutions. We will continue to nurture these collaborations and mutually enrich our research and development efforts. Examples of collaborative projects today are the development and use of advanced functional MRI imaging methods in neurosciences and clinical applications and studies of breast cancer with efficient MRS methods. We will continue to train students and postdoctoral fellows to be the future leaders in MR, to publish extensively, and to provide educational opportunities to the scientific and medical communities we serve. New technology and technological capabilities developed at the Center and as part of our extensive collateral research will be disseminated rapidly for widespread use in the national research community. Publications, conference presentations, annual reports and the internet will continue to form the backbone of our dissemination efforts.
Historically, the introduction of new MRI/MRS methods has had a profound impact on public health research. Unfortunately, many researchers do not have access to the latest MR technology because vendors'priorities often preclude their inclusion. CAMRT's record of accomplishment and the ever-evolving need for timely new technology of the type we propose compel the continuation of CAMRT as a national research resource.
|Shi, Xinwei; Yoon, Daehyun; Koch, Kevin M et al. (2017) Metallic implant geometry and susceptibility estimation using multispectral B0 field maps. Magn Reson Med 77:2402-2413|
|Monu, U D; Jordan, C D; Samuelson, B L et al. (2017) Cluster analysis of quantitative MRI T2 and T1? relaxation times of cartilage identifies differences between healthy and ACL-injured individuals at 3T. Osteoarthritis Cartilage 25:513-520|
|Sveinsson, B; Chaudhari, A S; Gold, G E et al. (2017) A simple analytic method for estimating T2 in the knee from DESS. Magn Reson Imaging 38:63-70|
|Carr, Valerie A; Bernstein, Jeffrey D; Favila, Serra E et al. (2017) Individual differences in associative memory among older adults explained by hippocampal subfield structure and function. Proc Natl Acad Sci U S A 114:12075-12080|
|Ni, Wendy W; Christen, Thomas; Zaharchuk, Greg (2017) Benchmarking transverse spin relaxation based oxygenation measurements in the brain during hypercapnia and hypoxia. J Magn Reson Imaging 46:704-714|
|Leuze, Christoph; Aswendt, Markus; Ferenczi, Emily et al. (2017) The separate effects of lipids and proteins on brain MRI contrast revealed through tissue clearing. Neuroimage 156:412-422|
|Gibbons, Eric K; Le Roux, Patrick; Vasanawala, Shreyas S et al. (2017) Body Diffusion Weighted Imaging Using Non-CPMG Fast Spin Echo. IEEE Trans Med Imaging 36:549-559|
|Cheng, Joseph Y; Zhang, Tao; Alley, Marcus T et al. (2017) Comprehensive Multi-Dimensional MRI for the Simultaneous Assessment of Cardiopulmonary Anatomy and Physiology. Sci Rep 7:5330|
|Chaudhari, Akshay S; Sveinsson, Bragi; Moran, Catherine J et al. (2017) Imaging and T2 relaxometry of short-T2 connective tissues in the knee using ultrashort echo-time double-echo steady-state (UTEDESS). Magn Reson Med 78:2136-2148|
|Park, Jae Mo; Khemtong, Chalermchai; Liu, Shie-Chau et al. (2017) In vivo assessment of intracellular redox state in rat liver using hyperpolarized [1-13 C]Alanine. Magn Reson Med 77:1741-1748|
Showing the most recent 10 out of 119 publications