The overall long-term goal ofthe Center for Magnetic Resonance and Optical Imaging (CMROI) is to develop cutting edge core Magnetic Resonance and Optical imaging technologies in support of the biomedical research community at the University of Pennsylvania and other institutions across the country to address clinical problems and to further the fundamental understanding of biophysical, physiological, structural, and functional properties of biological systems. Based on the driving biomedical projects identified by our collaborators, we developed the following four broad areas of Technological Research and Development (TR&D): The first TR&D project deals with the development of novel rotating frame MRI techniques for studying the structural, biochemical and metabolic aspects of cartilage, brain, and tumors, with direct application to Arthritis, Alzheimer's Disease and cancer. The second TR&D focuses on the development of quantitative perfusion MRI at ultra high field {7T) scanners, real time fMRI as well as methods for integrating perfusion MRI with optical imaging for the study of stroke and neurodegeneration. The 3rd TR&D develops novel image reconstruction strategies to overcome artifacts due to motion and to quantify the rapid dynamics of contrast agents in cancer and to acquire dynamic hyperpolarized gas MRI of the lungs. The final TR&D develops multi-modal state-of-the-art instrumentation combining optical imaging and MRI, and develops diffuse correlation spectroscopy (DCS) for blood flow monitoring/imaging of diseased tissues in stroke and breast cancer. The Resource emphasizes clinical translation of its TR&D work and actively collaborates on ongoing research projects. It provides service in the use of state-of-the-art MRI including a whole-body 7T research MRI scanner, optical imaging and hyperpolarized gas imaging systems, and software resources developed by the Resource. The Resource also maintains an extensive training and dissemination program in biomedical imaging and a dedicated wiki-based website. The Resource within the auspices of the Radiology department at the University of Pennsylvania remains committed to intellectual interchange and the interdisciplinary pursuit of basic and clinical medicine.

Public Health Relevance

Imaging technologies developed by the resource will have substantial impact on fundamental understanding, early diagnosis, and development of novel therapies for several diseases including Alzheimer's Disease, Arthritis, Cancer, Stroke, and chronic obstructive pulmonary disease (COPD).

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB015893-29
Application #
8469299
Study Section
Special Emphasis Panel (ZRG1-SBIB-Q (40))
Program Officer
Liu, Christina
Project Start
1997-09-30
Project End
2015-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
29
Fiscal Year
2013
Total Cost
$1,481,535
Indirect Cost
$553,634
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kim, Daeun; Lee, Hyo Min; Oh, Se-Hong et al. (2015) Probing signal phase in direct visualization of short transverse relaxation time component (ViSTa). Magn Reson Med 74:499-505
Wang, Ze (2014) Support vector machine learning-based cerebral blood flow quantification for arterial spin labeling MRI. Hum Brain Mapp 35:2869-75
Haris, Mohammad; Singh, Anup; Cai, Kejia et al. (2014) A technique for in vivo mapping of myocardial creatine kinase metabolism. Nat Med 20:209-14
Nanga, Ravi Prakash Reddy; DeBrosse, Catherine; Singh, Anup et al. (2014) Glutaminase catalyzes reaction of glutamate to GABA. Biochem Biophys Res Commun 448:361-4
Satterthwaite, Theodore D; Shinohara, Russell T; Wolf, Daniel H et al. (2014) Impact of puberty on the evolution of cerebral perfusion during adolescence. Proc Natl Acad Sci U S A 111:8643-8
Crescenzi, Rachelle; DeBrosse, Catherine; Nanga, Ravi Prakash Reddy et al. (2014) In vivo measurement of glutamate loss is associated with synapse loss in a mouse model of tauopathy. Neuroimage 101:185-92
Wetherill, Reagan R; Jagannathan, Kanchana; Lohoff, Falk W et al. (2014) Neural correlates of attentional bias for smoking cues: modulation by variance in the dopamine transporter gene. Addict Biol 19:294-304
Kim, Meeri N; Edlow, Brian L; Durduran, Turgut et al. (2014) Continuous optical monitoring of cerebral hemodynamics during head-of-bed manipulation in brain-injured adults. Neurocrit Care 20:443-53
Jain, Varsha; Buckley, Erin M; Licht, Daniel J et al. (2014) Cerebral oxygen metabolism in neonates with congenital heart disease quantified by MRI and optics. J Cereb Blood Flow Metab 34:380-8
Cai, Kejia; Xu, He N; Singh, Anup et al. (2014) Breast cancer redox heterogeneity detectable with chemical exchange saturation transfer (CEST) MRI. Mol Imaging Biol 16:670-9

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