Center for Magnetic Resonance Research at the University of Minnesota is an interdepartmental and interdisciplinary research laboratory that has been funded as a Biotechnology Research Resource (BTRR) during the last thirteen years. The central research focus of this BTRR is development and improvement of methodologies and technologies for high magnetic resonance (MR) imaging and spectroscopy, and providing state-of-the-art instrumentation, expertise and infrastructure to enable the faculty, trainees and staff of several institutions in the USA and abroad to carry out basic and applied biomedical research that utilizes these unique high magnetic field (4 to 16.4 Tesla) capabilities. The general aim of this application is to seek continued support for this Biomedical Technology Research Resource so as to pursue new methodological and technical developments and maintain a National Research Resource with unique instrumentation and expertise that is not readily available elsewhere. A central and primary aim of the Core projects is to develop techniques for obtaining simultaneous information on aspects of organ function, perfusion, oxygen extraction, metabolism, and anatomy in humans non-invasively, using the unique advantages provided by high magnetic fields, such as the high signal-to-noise ratio, increased susceptibility effects associated with blood for imaging brain function, longer T1s for measurement of tissue perfusion, increased chemical-shift resolution for improved detection of neurochemicals, and the use of magnetic isotopes of biologically active atoms, such as O-17, which are not accessible easily at low magnetic fields due to their low gyromagnetic ratio. These techniques have been and will continue to be utilized to support a large community of NIH funded researchers working in neurosciences, functional brain mapping, brain metabolism, metabolic disorders, and cardiac pathology and bioenergetics.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Biotechnology Resource Grants (P41)
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Special Emphasis Panel (ZRG1-SBIB-S (40))
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Liu, Christina
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University of Minnesota Twin Cities
Schools of Medicine
United States
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Liu, Jiaen; Zhang, Xiaotong; Schmitter, Sebastian et al. (2015) Gradient-based electrical properties tomography (gEPT): A robust method for mapping electrical properties of biological tissues in vivo using magnetic resonance imaging. Magn Reson Med 74:634-46
Deelchand, Dinesh K; Adanyeguh, Isaac M; Emir, Uzay E et al. (2015) Two-site reproducibility of cerebellar and brainstem neurochemical profiles with short-echo, single-voxel MRS at 3T. Magn Reson Med 73:1718-25
Corum, Curtis A; Idiyatullin, Djaudat; Snyder, Carl J et al. (2015) Gap cycling for SWIFT. Magn Reson Med 73:677-82
Kobayashi, Naoharu; Idiyatullin, Djaudat; Corum, Curt et al. (2015) SWIFT MRI enhances detection of breast cancer metastasis to the lung. Magn Reson Med 73:1812-9
Deelchand, Dinesh Kumar; Henry, Pierre-Gilles; Marja?ska, Ma?gorzata (2015) Effect of carr-purcell refocusing pulse trains on transverse relaxation times of metabolites in rat brain at 9.4 Tesla. Magn Reson Med 73:13-20
Liimatainen, Timo; Hakkarainen, Hanne; Mangia, Silvia et al. (2015) MRI contrasts in high rank rotating frames. Magn Reson Med 73:254-62
Kalavagunta, Chaitanya; Zhou, Xiangmin; Schmechel, Stephen C et al. (2015) Registration of in vivo prostate MRI and pseudo-whole mount histology using Local Affine Transformations guided by Internal Structures (LATIS). J Magn Reson Imaging 41:1104-14
Powell, Nathaniel J; Jang, Albert; Park, Jang-Yeon et al. (2015) Gradient rotating outer volume excitation (GROOVE): A novel method for single-shot two-dimensional outer volume suppression. Magn Reson Med 73:139-49
Gillick, Bernadette T; Krach, Linda E; Feyma, Tim et al. (2014) Primed low-frequency repetitive transcranial magnetic stimulation and constraint-induced movement therapy in pediatric hemiparesis: a randomized controlled trial. Dev Med Child Neurol 56:44-52
Kalavagunta, Chaitanya; Michaeli, Shalom; Metzger, Gregory J (2014) In vitro Gd-DTPA relaxometry studies in oxygenated venous human blood and aqueous solution at 3 and 7?T. Contrast Media Mol Imaging 9:169-76

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