Medical imaging has revolutionized clinical medicine. The development and deployment of modern medical imaging, barely 30 years ago, has been nothing short of stunning. The basic sciences have seen parallel technical developments with similar impact. The enormous resources applied to the clinical domain have pushed technology to higher resolution, specificity, and speed. The explosive growth of methods can overwhelm us with options and data. The goal of the Center for in Vivo Microscopy (CIVM) is to develop novel preclinical imaging tools and make these methods widely available to collaborators in the basic sciences.

Public Health Relevance

We propose here the next generation of preclinical imaging in which we will develop multimodality protocols that integrate the best of all the modalities to provide comprehensive insight into three major diseases - neurological disease, cardiovascular disease, and cancer.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Biotechnology Resource Grants (P41)
Project #
Application #
Study Section
Special Emphasis Panel (ZEB1-OSR-E (M1))
Program Officer
Liu, Christina
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Duke University
Schools of Medicine
United States
Zip Code
Xie, Luke; Dibb, Russell; Cofer, Gary P et al. (2015) Susceptibility tensor imaging of the kidney and its microstructural underpinnings. Magn Reson Med 73:1270-81
McMurray, Matthew S; Oguz, Ipek; Rumple, Ashley M et al. (2015) Effects of prenatal cocaine exposure on early postnatal rodent brain structure and diffusion properties. Neurotoxicol Teratol 47:80-8
Kaushik, S Sivaram; Freeman, Matthew S; Yoon, Suk W et al. (2014) Measuring diffusion limitation with a perfusion-limited gas--hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis. J Appl Physiol (1985) 117:577-85
Ashton, Jeffrey R; Befera, Nicholas; Clark, Darin et al. (2014) Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent. Contrast Media Mol Imaging 9:161-8
Lipinski, Robert J; Holloway, Hunter T; O'Leary-Moore, Shonagh K et al. (2014) Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate. PLoS One 9:e102603
Clark, Darin P; Badea, Cristian T (2014) Spectral diffusion: an algorithm for robust material decomposition of spectral CT data. Phys Med Biol 59:6445-66
Befera, Nicholas T; Badea, Cristian T; Johnson, G Allan (2014) Comparison of 4D-microSPECT and microCT for murine cardiac function. Mol Imaging Biol 16:235-45
Cao, Wei; Li, Wei; Han, Hui et al. (2014) Prenatal alcohol exposure reduces magnetic susceptibility contrast and anisotropy in the white matter of mouse brains. Neuroimage 102 Pt 2:748-55
Cleveland, Zackary I; Virgincar, Rohan S; Qi, Yi et al. (2014) 3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis. NMR Biomed 27:1502-14
Lee, Chang-Lung; Min, Hooney; Befera, Nicholas et al. (2014) Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation. Int J Radiat Oncol Biol Phys 88:686-93

Showing the most recent 10 out of 47 publications