The National Resource for Quantitative Funtional MRI has an Administrative Core that coordinates all BTRC activities, i.e. the development and dissemination of new MRI and MRS methodology for the assessment of the changing brain, as well as the training in its use. The PI of this core is Dr. Peter van Zijl, an experienced expert in MRI and MRS technology development, who has a longstanding experience in managing multi-center collaborations. Daily operation of the BTRC is the responsibility of Dr. van Zijl in close interaction with members of the Executive Committee, which consists of the PIs of the four technical research and development (TR&D) projects. The full committee meets bimonthly or whenever necessary. The TR&D PIs are all in close proximity and meet/interact closely at least on a weekly basis. The general goals of the Resource are formulated by this Executive Committee with guidance from the internal and external advisory committees. The main goal is to create an environment that allows method development through the push-pull interaction between the physicists and engineers of the TR&Ds and the application scientists and clinicians heading the collaborative projects. In addition, the BTRC supports many service projects as test beds of the methodology in important areas of application. The committee also assures that technology is further disseminated through presentations, training courses, and software and data transfer to interested sites (See Training and Dissemination Section). The Resource has carefully designed operating procedures to establish the above-mentioned collaborative and service projects and for the management of the facilities in terms of humans and animal safety and equitable access to the scanners and facilities. Plans for long-term maintenance of the facility assure that the BTRC can function successfully. The progress of the BTRC is overseen by an External Advisory Committee (EAC) consisting of experts in the fields for our TR&Ds. This committee meets annually to advise on scientific progress and on the progress of the center in terms of its goals of collaboration, service, training and dissemination. A yearly report is submitted to NIBIB as part of the annual progress report. In addition to the EAC, we have several local committees that provide oversight, including a protocol review committee that evaluates all research projects in terms of human safety and research quality. The BTRC has strong institutional support, as outlined in letters by the president of KKI and the Chairman of radiology at Johns Hopkins University. Our resource enters its final 5-year period as stipulated by the sunset policy of the NIBIB. We propose a transition strategy to continue our successful development of technology facilitated through multi-disciplinary collaboration.

Public Health Relevance

The National Resource for Quantitative Funtional MRI is governed by an Administrative Core that coordinates all its activities, including the development and dissemination of new magnetic resonance imaging (MRI) and spectroscopy (MRS) methodology for the assessment of the changing brain, as well as the training in its use. The progress of the Resource is overseen by an External Advisory Committee consisting of experts in the MR field. There also are several local committees that provide oversight, including a protocol review committee that evaluates all research projects in terms of human safety and research quality.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
2P41EB015909-16
Application #
9149841
Study Section
Special Emphasis Panel (ZEB1-OSR-B (M1)P)
Project Start
2000-07-01
Project End
2021-06-30
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
16
Fiscal Year
2016
Total Cost
$894,996
Indirect Cost
$150,567
Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
155342439
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Wijtenburg, S Andrea; Rowland, Laura M; Oeltzschner, Georg et al. (2018) Reproducibility of brain MRS in older healthy adults at 7T. NMR Biomed :e4040
Hou, Xirui; Liu, Peiying; Gu, Hong et al. (2018) Estimation of brain functional connectivity from hypercapnia BOLD MRI data: Validation in a lifespan cohort of 170 subjects. Neuroimage 186:455-463
van Bergen, J M G; Li, X; Quevenco, F C et al. (2018) Simultaneous quantitative susceptibility mapping and Flutemetamol-PET suggests local correlation of iron and ?-amyloid as an indicator of cognitive performance at high age. Neuroimage 174:308-316
Jiang, Dengrong; Liu, Peiying; Li, Yang et al. (2018) Cross-vendor harmonization of T2 -relaxation-under-spin-tagging (TRUST) MRI for the assessment of cerebral venous oxygenation. Magn Reson Med 80:1125-1131
Mohamed, M; Barker, P B; Skolasky, R L et al. (2018) 7T Brain MRS in HIV Infection: Correlation with Cognitive Impairment and Performance on Neuropsychological Tests. AJNR Am J Neuroradiol 39:704-712
Xu, Feng; Li, Wenbo; Liu, Peiying et al. (2018) Accounting for the role of hematocrit in between-subject variations of MRI-derived baseline cerebral hemodynamic parameters and functional BOLD responses. Hum Brain Mapp 39:344-353
van Bergen, Jiri M G; Li, Xu; Quevenco, Frances C et al. (2018) Low cortical iron and high entorhinal cortex volume promote cognitive functioning in the oldest-old. Neurobiol Aging 64:68-75
van Zijl, Peter C M; Lam, Wilfred W; Xu, Jiadi et al. (2018) Magnetization Transfer Contrast and Chemical Exchange Saturation Transfer MRI. Features and analysis of the field-dependent saturation spectrum. Neuroimage 168:222-241
Gong, Tao; Xiang, Yuanyuan; Saleh, Muhammad G et al. (2018) Inhibitory motor dysfunction in parkinson's disease subtypes. J Magn Reson Imaging 47:1610-1615
Stivaros, Stavros; Garg, Shruti; Tziraki, Maria et al. (2018) Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA). Mol Autism 9:12

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