The fabrication of complex engineered tissues remains a grand challenge in regenerative medicine. These complex tissues ? bone, cartilage, vasculature, and cardiac ? are characterized by dense cellularity, patterned cellular composition, and controlled matrix presentation. The proposed Biomedical Technology Resource Center (BTRC) will address this critical need by applying three-dimensional printing (3DP) strategies to the engineering of complex tissues. This BTRC brings together research leaders at the University of Maryland, Rice University, and Wake Forest University, all highly regarded collaborators in the field, to lead the development of the Center for Engineering Complex Tissues (CECT, [sees-t]). Strong and effective administrative leadership will maximize productivity, enhance ongoing collaborations, and ensure sound fiscal and compliance management for this BTRC. The technical components of CECT consist of 3 Technology Research and Development Projects (TR&Ds), 6 Collaborative Projects (CPs), and 6 Service Projects (SPs). An External Advisory Committee (EAC), that will guide and advise the strategic direction of the Center, will be assembled from world-renowned researchers with biomedical expertise relevant to the CECT. A Local Executive Committee (LEC) will coordinate the effort across the participating institutions involved in the day-to- day operations of the Center. We will also focus on growing a community engaged in developing and utilizing complex engineered tissues by offering a series of programs to help develop and establish these technologies. Communications programs will also be developed for the dissemination of the Center?s activities to enable a broader use of the technologies. The long-term plan for the CECT is that it will become a national hub for transforming current 3DP and tissue engineering technologies into new and improved platforms for everyday uses in regenerative medicine and biomedical device development.

Public Health Relevance

Cell-based constructs and biomaterial formulations have enormous potential for innovation for the next- generation of clinically relevant engineered tissues. To this end, we aim to develop the Center for Engineering Complex Tissues that will be a national and international resource for regenerative medicine. By leveraging our team?s longstanding bioengineering, biomaterials, and three-dimensional printing expertise, we will produce novel tissue engineered constructs with innovative properties and transplantation capabilities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
1P41EB023833-01
Application #
9279979
Study Section
Special Emphasis Panel (ZEB1-OSR-D (J1)P)
Program Officer
Selimovic, Seila
Project Start
2017-04-15
Project End
2022-01-31
Budget Start
2017-04-15
Budget End
2018-01-31
Support Year
1
Fiscal Year
2017
Total Cost
$1,663,147
Indirect Cost
$171,864
Name
University of Maryland College Park
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
790934285
City
College Park
State
MD
Country
United States
Zip Code
20742
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