Abstract

A shared 900 MHz NMR facility will be established for the Central California area, to be housed in the new QB3 Institute (Institute for Quantitative Biomedical Research) at the University of California Berkeley. The instrument will be available to investigators throughout the region. Specific proposals are included from investigators at UC Berkeley, Stanford, UC San Francisco, UC Davis, Lawrence Livermore National Lab and Genentech. Time on the instrument will be allocated to maximize its application to problems which challenge the limits of current NMR capability. Systems under study will include large viral and ribosomal RNAs, VS ribozyme, viral protein-RNA interactions, metalloprotein heine oxygenases, TNF ligand and receptor interactions, bacterial transcriptional activators, proteins studied inside cells, cytokines and their receptors, and proteins involved in DNA repair and their complexes. Support for carrying out state of the art spectroscopy, libraries of pulse sequences and their documentation, and general user guides will be provided by staff members in the facility. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
1P41GM068933-01
Application #
6684038
Study Section
Special Emphasis Panel (ZRG1-SSS-A (40))
Program Officer
Wehrle, Janna P
Project Start
2003-07-15
Project End
2008-06-30
Budget Start
2003-07-15
Budget End
2004-06-30
Support Year
1
Fiscal Year
2003
Total Cost
$5,000,000
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Hu, Xirui; Lim, Pharath; Fairhurst, Rick M et al. (2018) Synthesis and Study of the Antimalarial Cardamom Peroxide. Tetrahedron 74:3358-3369
Weeks, Amy M; Wang, Ningkun; Pelton, Jeffrey G et al. (2018) Entropy drives selective fluorine recognition in the fluoroacetyl-CoA thioesterase from Streptomyces cattleya. Proc Natl Acad Sci U S A 115:E2193-E2201
Zhang, Yizhe; Chan, Peggy P Y; Herr, Amy E (2018) Rapid Capture and Release of Nucleic Acids through a Reversible Photo-Cycloaddition Reaction in a Psoralen-Functionalized Hydrogel. Angew Chem Int Ed Engl 57:2357-2361
Mukai, Ken; de Sant'Ana, Danilo Pereira; Hirooka, Yasuo et al. (2018) Bioinspired chemical synthesis of monomeric and dimeric stephacidin A congeners. Nat Chem 10:38-44
Tong, Michael; Pelton, Jeff G; Gill, Michelle L et al. (2017) Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites. Nat Commun 8:2160
Condakes, Matthew L; Hung, Kevin; Harwood, Stephen J et al. (2017) Total Syntheses of (-)-Majucin and (-)-Jiadifenoxolane A, Complex Majucin-Type Illicium Sesquiterpenes. J Am Chem Soc 139:17783-17786
Fong, Jiunn Cn; Rogers, Andrew; Michael, Alicia K et al. (2017) Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms. Elife 6:
Holstlaw, Taylor A; Mahomed, Mavish; Brier, Livia W et al. (2017) Biopolymer Molecular Weight Can Modulate the Wound Healing Efficacy of Multivalent Sonic Hedgehog-Hyaluronic Acid Conjugates. Biomacromolecules 18:2350-2359
Kulkarni, Rishikesh U; Yin, Hang; Pourmandi, Narges et al. (2017) A Rationally Designed, General Strategy for Membrane Orientation of Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes. ACS Chem Biol 12:407-413
Reed, Nilgun Isik; Tang, You-Zhi; McIntosh, Joel et al. (2016) Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective ?v?1 Integrin Inhibitors. ACS Med Chem Lett 7:902-907

Showing the most recent 10 out of 37 publications