The fundamental goal of the Driving Biomedical Projects (DBPs) portfolio is to provide synergism, motivation, and act as a catalyst that drives the Washington University (WU) Biomedical Mass Spectrometry (MS) Resource personnel to develop and advance novel MS technologies, techniques, and methods (i.e., TRDs) that overcome technical challenges that inhibit progress on critical biomedical research questions or the biomolecular basis for a significant clinical disorder. Our DBPs provide a challenging biological platform or context upon which we can test, develop, refine, enhance, and advance new MS technologies and techniques. DBPs give purpose and compel Resource personnel to brainstorm, develop, custom-design, test, and apply MS technology and techniques in novel and innovative directions. When successful, they provide for the biomedical research community new tools that can be applied to solve intractable analytical problems. Our DBP portfolio has been carefully integrated with our proposed TRD themes, and includes 7 new, 29 ongoing, and 30 DBPs completed from 2009-13.

Public Health Relevance

-Public Health Relevance. The Washington University Biomedical Mass Spectrometry Resource has a longstanding history as an active and productive citizen in the NIH Biotechnology Research Resources community. We propose to extend our mission by advancing mass spectrometry technology, development, and research, applying these discoveries to answer critical biomedical research questions, and training the next generation of researchers, towards the ultimate goal of improving public health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
5P41GM103422-41
Application #
9412485
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
41
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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Ohlemacher, Shannon I; Giblin, Daryl E; d'Avignon, D André et al. (2017) Enterobacteria secrete an inhibitor of Pseudomonas virulence during clinical bacteriuria. J Clin Invest 127:4018-4030
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