This proposal describes our plans for the third renew^al ofthe Center for Integrated Biomedical Computing (CIBC), hosted by the Scientific Computing and Imaging (SCI) Institute at the University of Utah. The CIBC is a research resource that produces open-source software tools for biomedical image-based modeling, biomedical simulation and estimation, and the visualization of biomedical data. The software tools created by the Center are supported by a critical mass of research in scientific computing housed within the SCI Institute. These software tools, the research that underlies them, and the driving biological projects and collaborations that motivate their development are unified by a single vision: to develop the role of image-based modeling and analysis in biomedical science and clinical practice. The overarching goal ofthis proposal is to advance the state of practice in biomedical computing and its applications both to biomedical science and to the the translation ofthis science to chnical practice. We seek to achieve this goal by making advanced computation tools, tailored to the specific domains of image-based modeling, simulation, estimation, and visualization, accessible to scientists, engineers, and physicians by releasing readily usable, open-source software. We work closely with these users of our software, providing advice, technical support, workshops, and education to enhance their success with the tools we provide. Our long-term vision is to make scientific computing so useful and user friendly a tool, that it becomes a transparent and ubiquitous aspect of clinical and scientific practice.

Public Health Relevance

Our commitment to empowering researchers through scientific computing is apparent in the nunnber and breadth of the driving biological projects (DBFs) we wish to pursue and in the central role these projects play in all decisions within the Center. Many of our DBFs now have a very clinical focus.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
5P41GM103545-16
Application #
8711516
Study Section
Special Emphasis Panel (ZRG1-BST-J (40))
Program Officer
Friedman, Fred K
Project Start
2000-09-01
Project End
2015-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
16
Fiscal Year
2014
Total Cost
$949,543
Indirect Cost
$268,422
Name
University of Utah
Department
None
Type
Organized Research Units
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Fiederer, L D J; Vorwerk, J; Lucka, F et al. (2016) The role of blood vessels in high-resolution volume conductor head modeling of EEG. Neuroimage 128:193-208
Aras, Kedar; Burton, Brett; Swenson, Darrell et al. (2016) Spatial organization of acute myocardial ischemia. J Electrocardiol 49:323-36
Erem, Burak; Martinez Orellana, Ramon; Hyde, Damon E et al. (2016) Extensions to a manifold learning framework for time-series analysis on dynamic manifolds in bioelectric signals. Phys Rev E 93:042218
Noro, Mahito; Zhu, Xin; Enomoto, Yoshinari et al. (2016) Decreased Defibrillation Threshold and Minimized Myocardial Damage With Left Axilla Implantable Cardioverter Defibrillator Implantation. Circ J 80:878-86
Noro, Mahito; Zhu, Xin; Enomoto, Yoshinari et al. (2016) Efficacy and Myocardial Injury With Subcutaneous Implantable Cardioverter Defibrillators - Computer Simulation of Defibrillation Shock Conduction. Circ J 80:85-92
Tong, Xin; Edwards, John; Chen, Chun-Ming et al. (2016) View-Dependent Streamline Deformation and Exploration. IEEE Trans Vis Comput Graph 22:1788-801
Kindlmann, Gordon; Chiw, Charisee; Seltzer, Nicholas et al. (2016) Diderot: a Domain-Specific Language for Portable Parallel Scientific Visualization and Image Analysis. IEEE Trans Vis Comput Graph 22:867-76
Holman, Holly A; Tran, Vy M; Kalita, Mausam et al. (2016) BODIPY-Conjugated Xyloside Primes Fluorescent Glycosaminoglycans in the Inner Ear of Opsanus tau. J Assoc Res Otolaryngol 17:525-540
Chung, E; Marchetti, M A; Scope, A et al. (2016) Towards three-dimensional temporal monitoring of naevi: a comparison of methodologies for assessing longitudinal changes in skin surface area around naevi. Br J Dermatol 175:1376-1378
Oguz, Ipek; Cates, Josh; Datar, Manasi et al. (2016) Entropy-based particle correspondence for shape populations. Int J Comput Assist Radiol Surg 11:1221-32

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