Tech-2 Technology Development -2 describes the new features that we need to add to Xenbase in order to achieve our overall goals. Xenbase has a long list of essential additions and upgrades to be performed. This prioritized list was developed through feedback from the External Advisory Board (EAB), the Xenopus PI meeting and user surveys. These projects will require work at multiple levels of our software stack, from database modifications, web application development and user interfaces, to upgrades, maintenance, testing, bug fixing. Our experienced development team will continue to seek input from other MODs leveraging solutions that have working in other Resources.
Our specific aims are:
Aim 1 - Deploy JBrowse and WebApollo Aim 2 - Develop Support Vector Machine tools Aim 3 - Build support for new content types including robust graph display and visualization tools, protein-protein and gene interaction content, Non-coding RNAs and alternative splicing support and genome editing support.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Biotechnology Resource Grants (P41)
Project #
5P41HD064556-08
Application #
9380972
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
2017-12-01
Budget End
2018-11-30
Support Year
8
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
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Vize, Peter D; Zorn, Aaron M (2017) Xenopus genomic data and browser resources. Dev Biol 426:194-199
Session, Adam M; Uno, Yoshinobu; Kwon, Taejoon et al. (2016) Genome evolution in the allotetraploid frog Xenopus laevis. Nature 538:336-343
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Vize, Peter D; Liu, Yu; Karimi, Kamran (2015) Database and Informatic Challenges in Representing Both Diploid and Tetraploid Xenopus Species in Xenbase. Cytogenet Genome Res 145:278-82
Grant, Ian M; Balcha, Dawit; Hao, Tong et al. (2015) The Xenopus ORFeome: A resource that enables functional genomics. Dev Biol 408:345-57
James-Zorn, Christina; Ponferrada, Virgillio G; Burns, Kevin A et al. (2015) Xenbase: Core features, data acquisition, and data processing. Genesis 53:486-97

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