The goals of this project are to design, implement, and make generally available a database containing correlated information about the genome of budding yeast (Saccharomyces cerevisiae). The database consists of four central elements: the genetic map, the physical map, the DNA sequence, and biological information (mainly summaries of what is known about the functions of the genes, their products, their interactions and supporting bibliographic references for all of the above). These data have been assimilated into SacchDB, using the ACEDB genomic database software (both a UNIX and a Macintosh version are fully supported) and into the Nucleus Server, an on-line system of our own design that allows very fast responses to simple map-based queries over the Internet. The Saccharomyces Genome Database (SGD) staff will, under this program, maintain, disseminate, update and enhance the database, providing access by CD-ROM, Gopher, Anonymous FTP, and World Wide Web (WWW) as well as the Nucleus server through a Macintosh client and a gateway to Gopher. It is anticipated that the sequence of the entire genome of Saccharomyces cerevisiae will be available some time in 1997. The expectation is that the SGD will be a suitable comprehensive genome database by that time so that the genome research community and the broader biomedical research community can obtain the maximum benefit from having the first complete sequence of a eukaryotic genome.

National Institute of Health (NIH)
National Human Genome Research Institute (NHGRI)
Biotechnology Resource Grants (P41)
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Special Emphasis Panel (SRC (06))
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Stanford University
Schools of Medicine
United States
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Kramer, Michael H; Farré, Jean-Claude; Mitra, Koyel et al. (2017) Active Interaction Mapping Reveals the Hierarchical Organization of Autophagy. Mol Cell 65:761-774.e5
Hellerstedt, Sage T; Nash, Robert S; Weng, Shuai et al. (2017) Curated protein information in the Saccharomyces genome database. Database (Oxford) 2017:
MacPherson, Kevin A; Starr, Barry; Wong, Edith D et al. (2017) Outreach and online training services at the Saccharomyces Genome Database. Database (Oxford) 2017:
Balakrishnan, Rama; Park, Julie; Karra, Kalpana et al. (2012) YeastMine--an integrated data warehouse for Saccharomyces cerevisiae data as a multipurpose tool-kit. Database (Oxford) 2012:bar062
Chan, Esther T; Cherry, J Michael (2012) Considerations for creating and annotating the budding yeast Genome Map at SGD: a progress report. Database (Oxford) 2012:bar057
Cherry, J Michael; Hong, Eurie L; Amundsen, Craig et al. (2012) Saccharomyces Genome Database: the genomics resource of budding yeast. Nucleic Acids Res 40:D700-5
Gene Ontology Consortium (2012) The Gene Ontology: enhancements for 2011. Nucleic Acids Res 40:D559-64
Park, Julie; Costanzo, Maria C; Balakrishnan, Rama et al. (2012) CvManGO, a method for leveraging computational predictions to improve literature-based Gene Ontology annotations. Database (Oxford) 2012:bas001
Skrzypek, Marek S; Hirschman, Jodi (2011) Using the Saccharomyces Genome Database (SGD) for analysis of genomic information. Curr Protoc Bioinformatics Chapter 1:Unit 1.20.1-23
Rangarajan, Arun; Schedl, Tim; Yook, Karen et al. (2011) Toward an interactive article: integrating journals and biological databases. BMC Bioinformatics 12:175

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