Caenorhabditis elegans is a major model system for basic biological and biomedical research and the first animal for which there is a complete description of its genome, anatomy and development. Three years of funding is requested to extend an existing database, ACeDB, into WormBase, a Model Organism Database (MOD), with complete coverage of core genomic, genetic, anatomical and functional information about this nematode. Such a database is necessary to allow the entire biomedical research community as well as C. elegans researchers to make full use of the 97,000,000 basepair genomic sequence, with its 19,000 genes, and the results of intensive molecular genetic analysis of C. elegans. The two top priorities will thus be data curation and user interface. WormBase will include up-to-date annotation of the genomic sequence, the current genetic and physical maps and many experimental data connected to the function and interactions of cells and genes, as well as development and organismal behavior. Direct access to the sources of biological material, such as the strain collection of the Caenorhabditis Genetics Center and direct links to data sets maintained by others will be provided. Data will be recovered from the existing resources, from direct contribution of the individual laboratories, and from the literature. While WormBase will act as a central forum through which every laboratory will be able to contribute constructively to the global effort to fully comprehend this metazoan organism, WormBase professional curators will ensure detailed attribution of data sources and check consistency and integrity. To facilitate communication WormBase will use wherever possible terminology and style concordant with other model organism databases. WormBase will be Web-based and easy to use. The underlying database manager will remain the object-based Acedb database system, which can also be used locally on any platform. Minor enhancements to Acedb will meet the changing priorities of the data sets. Coordination of the project and the main curation site will be at Caltech under the supervision of a C. elegans biologist. Curation and annotation of genomic sequence will take place at the two sequencing centers, the Sanger Centre and Washington University, that generated the entire genome sequence. The Montpellier team will develop interfaces to new large-scale projects such as systematic inactivation of genes, systematic analysis of gene expression, and the large scale cDNA project of Kohara. Development of new user interfaces will take place at Cold Spring Harbor, currently providing Web-based access to ACeDB.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Biotechnology Resource Grants (P41)
Project #
5P41HG002223-02
Application #
6388352
Study Section
Ethical, Legal, Social Implications Review Committee (GNOM)
Program Officer
Good, Peter J
Project Start
2000-07-20
Project End
2003-06-30
Budget Start
2001-08-01
Budget End
2002-06-30
Support Year
2
Fiscal Year
2001
Total Cost
$964,048
Indirect Cost
Name
California Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125
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