Recently ion channels have been shown to interact with cytoskeleton proteins, like PSD families, including PSD93, 95, 97. These PSD proteins all have PDZ domains, which are responsible for interacting with the so-called XV motif at the very C-terminal of the ion channels like K+ channel and glutamate receptors (e.g., NR2A-D). Another PDZ protein, GRIP, interacts with another glutamate receptor, GluR2, which has a different C terminal motif: ISEKI. What determines this specificity? We are now analyzing the crystal structure of the PSD95 PDZ-XV complex. We are also interested in obtaining the crystal structure of GRIP-ISEKI complex. Thus we will be able to pinpoint the determinants responsible for this specific interaction.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001081-22
Application #
6119283
Study Section
Project Start
1999-07-01
Project End
2000-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
22
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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