The overall objective is to provide and maintain a forefront laboratory whose on-going core research and development is able to effectively support outstanding collaborative projects and respond to shorter term service needs of the community as they arise. The long term goal is to stimulate new research by making advanced laser systems available for research in the biomedical area. The laboratory is committed to respond positively to any user request that is good science. The Research concerns time resolved spectroscopy in photosynthesis, vision, bacterial membranes, hemoproteins, nucleic acids, polypeptides, proteins and membranes involving processes of energy transfer, electron transfer, proton transfer, isomerization, ligand dynamics, ion transfer, allosteric effects, chain dynamics, vibrational dynamics, collective motions, molecular reorientation and transport. The techniques used include transient absorption in the UV/VIS and IR regions with time resolution from fs to ms, transient fluorescence with time resolution from 100 fs to mus, and Raman spectroscopy. Specifically core projects on: improvement of time correlated single photon counting, picosecond and nanosecond instrumentation, transient infrared and femtosecond absorption spectroscopy; research on proton and electron transfer; coherent processes in biology; and studies of generic intrinsic probes using IR spectroscopy.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
2P41RR001348-11
Application #
3103858
Study Section
Special Emphasis Panel (SSS (R2))
Project Start
1982-08-01
Project End
1997-07-31
Budget Start
1992-09-25
Budget End
1993-07-31
Support Year
11
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Sheth, Rahul A; Arellano, Ronald S; Uppot, Raul N et al. (2015) Prospective trial with optical molecular imaging for percutaneous interventions in focal hepatic lesions. Radiology 274:917-26
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Courter, Joel R; Abdo, Mohannad; Brown, Stephen P et al. (2014) The design and synthesis of alanine-rich ?-helical peptides constrained by an S,S-tetrazine photochemical trigger: a fragment union approach. J Org Chem 79:759-68
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Kuroda, Daniel G; Singh, Prabhat K; Hochstrasser, Robin M (2013) Differential hydration of tricyanomethanide observed by time resolved vibrational spectroscopy. J Phys Chem B 117:4354-64
Singh, Prabhat K; Kuroda, Daniel G; Hochstrasser, Robin M (2013) An ion's perspective on the molecular motions of nanoconfined water: a two-dimensional infrared spectroscopy study. J Phys Chem B 117:9775-84
Chuntonov, Lev; Ma, Jianqiang (2013) Quantum process tomography quantifies coherence transfer dynamics in vibrational exciton. J Phys Chem B 117:13631-8
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Goldberg, Jacob M; Speight, Lee C; Fegley, Mark W et al. (2012) Minimalist probes for studying protein dynamics: thioamide quenching of selectively excitable fluorescent amino acids. J Am Chem Soc 134:6088-91

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