The overall objective of the BRC initiative is to provide technologies suitable to resolve the functional complexity of the living cell with emphasis on diffusive boundary layers surrounding cells and tissues and correlating the data to the activity of the cell in sub-cellular domains. That initiative requires a continuous development of electrochemical micro-sensors and their applications for detection of important biological molecules through collaborative research projects. This proposal is a continuation of previous research efforts in scope of sensor speed, selectivity and 'poisoning' by compounds used in experimental conditions. Major improvement of the sensor performance is claimed in sensor construction. The applicants plan to pursue the sensor construction with a commercial initiative -BioCurrents Research Inc. (BRI) - assuming successful funding of Phase II STTR award or to continue independently. Furthermore, it is planned to continue the development of the BioKelvin probe now renamed to the Bioelectric Field Imager (BFI) device with a goal of clinical application to skin disease within a collaborative work with General Medicine. There are 4 specific aims within the 4A: 1; (1) to continue investigation of ISE in 'self-referencing mode' (Seris), (2) to continue development of amperometric -redox based electrodes in self-referencing mode (Sera) (a) by continuing further development of existing electrodes and (b) by initiating development of application of new sensors design -sol-gels and Os gels, (3) to continue development and innovation in hardware and software support, and (4) to improve production of the Whalen design amperometric O2 sensor.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001395-26
Application #
7340122
Study Section
Special Emphasis Panel (ZRG1-BPC-H (40))
Program Officer
Levy, Abraham
Project Start
1997-12-01
Project End
2009-11-30
Budget Start
2007-12-01
Budget End
2008-11-30
Support Year
26
Fiscal Year
2008
Total Cost
$1,128,199
Indirect Cost
Name
Marine Biological Laboratory
Department
Type
DUNS #
001933779
City
Woods Hole
State
MA
Country
United States
Zip Code
02543
Demidenko, Eugene; Glaholt, S P; Kyker-Snowman, E et al. (2017) Single toxin dose-response models revisited. Toxicol Appl Pharmacol 314:12-23
Chowanadisai, Winyoo; Messerli, Shanta M; Miller, Daniel H et al. (2016) Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors. PLoS One 11:e0151089
De Martino, Federico; Moerel, Michelle; Ugurbil, Kamil et al. (2015) Less noise, more activation: Multiband acquisition schemes for auditory functional MRI. Magn Reson Med 74:462-7
Van Mooy, Benjamin A S; Hmelo, Laura R; Fredricks, Helen F et al. (2014) Quantitative exploration of the contribution of settlement, growth, dispersal and grazing to the accumulation of natural marine biofilms on antifouling and fouling-release coatings. Biofouling 30:223-36
Brodsky, Alexander S; Fischer, Andrew; Miller, Daniel H et al. (2014) Expression profiling of primary and metastatic ovarian tumors reveals differences indicative of aggressive disease. PLoS One 9:e94476
De Martino, Federico; Zimmermann, Jan; Muckli, Lars et al. (2013) Cortical depth dependent functional responses in humans at 7T: improved specificity with 3D GRASE. PLoS One 8:e60514
De Martino, Federico; Moerel, Michelle; van de Moortele, Pierre-Francois et al. (2013) Spatial organization of frequency preference and selectivity in the human inferior colliculus. Nat Commun 4:1386
Vang, Souriya; Wu, Hsin-Ta; Fischer, Andrew et al. (2013) Identification of ovarian cancer metastatic miRNAs. PLoS One 8:e58226
Chowanadisai, Winyoo; Graham, David M; Keen, Carl L et al. (2013) Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Proc Natl Acad Sci U S A 110:9903-8
De Martino, Federico; Schmitter, Sebastian; Moerel, Michelle et al. (2012) Spin echo functional MRI in bilateral auditory cortices at 7 T: an application of B? shimming. Neuroimage 63:1313-20

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